Analysis of Prostanoid receptor subtypes in interstitial pneumonitis

间质性肺炎前列腺素受体亚型分析

• 批准号: 14570427
• 负责人: ENDO Hirahito
• 金额: $ 2.05万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570427/
• 关键词: interstitial pneumonitis; bleomycin; 15 deoxy-prostaglandin J2; Lipoxin; Thromboxane; Scleroderma; Leukotriene; ロイトリエン; プロスタグランジン; プロスタグランジン受容体; PPARγ; プロスタクランジンE_2; プロスタブランジンE受容体

1.15 deoxy-prostaglandin J2 (15d-PGJ2) suppress mouse interstitial pneumonitis induced bleomycin. 15d-PGJ2 is a legand of nuclear receptor, peroxysome-proliferator activated receptor gamma. PPAR gamma highly expressed in lung lesion of bleomycin-induced interstitial pneumonitis15d-PGJ2 is a stable metabolite of PGD2. PGD syntase retrovirally transfected fibroblasts also inhibited interstitial pneumonitis.2.15d-PGJ2 inhibited skin sclerosis and lung fibrosis in bleomycin-induced mouse scleroderma model. In this disease model mast cells highly infiltrated in skin and lung and plasma histamine levels increased in this model. 15-dPGJ2 inhibited mast cell activation, histamine release.3.Lipoxin A4 receptor (ALX) increased bleomycin-induced interstitial pneumonitis. Lipoxin A4 inhibited TGF beta induced lung fibroblast proliferation and collagen synthesis. And TXA2 receptor also induced in induced. ALX induced by TX syntase inhibitor.

1.15脱氧前列腺素J2（15 d-PGJ 2）抑制博莱霉素诱导的小鼠间质性肺炎。15 d-PGJ 2是核受体过氧体增殖物激活受体γ（peroxosome-proliferatoractivatedreceptor gamma）的分支。PPAR γ在博莱霉素诱导的间质性肺炎的肺病变中高度表达15 d-PGJ 2是PGD 2的稳定代谢产物。PGD合成酶逆转录病毒转染的成纤维细胞也抑制间质性肺炎。2. 15 d-PGJ 2抑制博莱霉素诱导的小鼠硬皮病模型中的皮肤硬化和肺纤维化。在该疾病模型中，肥大细胞在皮肤和肺中高度浸润，并且在该模型中血浆组胺水平增加。15-dPGJ 2抑制肥大细胞活化、组胺释放。3.脂氧素A4受体（ALX）增加博莱霉素诱导的间质性肺炎。脂氧素A4抑制TGF β诱导的肺成纤维细胞增殖和胶原合成。TXA_2受体也被诱导。TX合成酶抑制剂诱导的ALX。

项目成果

Differential expression of leukotoriene B4 Receptor subtype (BLT1 and BLT2) in human synovial tissues

人滑膜组织中白三烯 B4 受体亚型（BLT1 和 BLT2）的差异表达

• 发表时间: 2003
• 期刊: J.Rheum 30
• 作者: Hashimoto.A.Endo;H et al.
• 通讯作者: H et al.

Down-regulation of Lipoxin A4 receptor by thromboxan A2 signaling in RAW264.7 cells in vitro and bleomycin-induc

体外和博莱霉素诱导的 RAW264.7 细胞中血栓素 A2 信号传导对脂氧素 A4 受体的下调

• 发表时间: 2004
• 期刊: Biomedicin pharmtherapy 58
• 作者: Sato;Y.EndoH;et al.
• 通讯作者: et al.

Amano H, Endo H et al.: "Host prostaglandin E_2・EP3 signaling regulates Tumor-associated angiogenesis and tumor growth"J.Exp Med. 20. 221-232 (2003)

Amano H、Endo H 等人：“宿主前列腺素 E_2·EP3 信号传导调节肿瘤相关血管生成和肿瘤生长”J.Exp Med 20. 221-232 (2003)

Murakami Y, Endo H et al.: "Inhibition of Monosodium Urate Mono hydrate Crystal-Induced Acute Inflammation"Arthritis Rheum. 48. 2931-2941 (2003)

Murakami Y、Endo H 等人：“尿酸钠一水合物晶体诱导的急性炎症的抑制”关节炎大黄。

Retrovirally introduced prostaglandin D2 syntase suppresses lung injury induced by bleomycin

逆转录病毒引入前列腺素 D2 合酶抑制博来霉素诱导的肺损伤

• 发表时间: 2003
• 期刊: Am J Resp cell Mol Biol 28
• 作者: Ando;M.;Endo;H.et al.
• 通讯作者: H.et al.