Role of molecular chaperon in gastric mucosal injury and restoration

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Many recent studies have indicated the importance of heat shock (proteins (HSPs) for survival of cells under stress conditions. Some HSPs are known to be involved in cytoprotection against environmental stresses mediated by their function as a "molecular chaperon". We have reported that a 72-kDa heat shock protein (HSP72, stress-inducible HSP7O) plays essential role in the gastric and colonic mucosa in vivo.In the present study demonstrated that1)When gastric mucosal HSP72 is induced by zinc derivatives, protective ability and wound restoration are enhanced in vitro and in vivo.2)Over-expression of HSP72 by gene-transfection clearly enhanced cytoprotective ability against ethanol-induced cell damage and wound restoration in cultured gastric mucosal cells.Our results suggested that expression of HSP72 could play important roles not only in cytoprotection but also in mucosal wound restoration mediated by the function as a molecular chaperon of HSP72.