Normal database of cerebral blood flow and cerebral oxygen metabolism measured with PET and O-15 labeled gas.

用PET和O-15标记气体测量的脑血流量和脑氧代谢的正常数据库。

• 批准号: 14570900
• 负责人: SENDA Michio
• 金额: $ 2.11万
• 依托单位: Institute of Biomedical Research and Innovation
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570900/
• 关键词: PET; O-15 labeled gas; regional cerebral blood flow; regional cerebral oxygen metabolism; regional cerebral oxygen extraction fraction; multicenter study; normal database

Measurement of CBF, cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF), and CMRO_2 by positron emission tomography (PET) with ^<15>O-labeled carbon dioxide (C^<15>O_2) or ^<15>O-labeled water 8H_2^<15>O), ^15O-labeled carbon monoxide (C^<15>O), or ^<15>O-labeled oxygen (^<15>O_2) is useful for diagnosis and treatment planning in cases of cerebrovascular disease. The measured values theoretically depend on factors that differ between PET centers. PET data of 70 healthy volunteers from 11 PET centers were analyzed. Steady-state method was used in 7 centers for C^<15>O_2 and in 8 centers for ^<15>O_2. Non-steady-state method was used in the other centers. The partition coefficient of water varied from 0.8 to 1.0 depending on the centers. Overall mean ± SD values for cerebral cortical regions were : CBF = 44.4 ± 6.5 mL/100 mL/min ; CBV = 3.8 ± 0.7 mL/100 mL ; OEF = 0.44 ± 0.06 ; CMRO_2 = 3.3 ± 0.5 mL/100 mL/min ; the variations being acceptable small, suggesting the practicability of building a normal database for ^<15>O-labeled gas sturdy. The CBF image of each subject was further spatially normalized into the standard Talairach coordinates system using SPM99, and the other three parametric images were transformed with the same transformation. This procedure created the average normal images of each parameter in the standard coordinates system, which may provide normal values for each brain region in the image format.

应用正电子发射断层扫描（PET）技术，用~（15）<15>O标记的CO_2（C^<15>O_2）或~（15）<15>O标记的水（8H_2<15>）、~（15）O标记的CO（C^ O）或~（15<15>）O标记<15>的氧（<15>O）进行CBF、脑血容量（CBV）、脑氧摄取分数（OEF）和CMRO_2的测定，对脑血管病的诊断和治疗有重要意义。理论上，测量值取决于PET中心之间不同的因素。分析了11个PET中心70名健康志愿者的PET数据。用稳态法计算了7个C^ O_2中心<15>和8个C ^ O_2中心<15>。其他中心采用非稳态方法。水的分配系数从0.8到1.0变化取决于中心。大脑皮质区的总体平均值± SD值为：CBF = 44.4 ± 6.5 mL/100 mL/min ; CBV = 3.8 ± 0.7 mL/100 mL ; OEF = 0.44 ± 0.06 ; CMRO_2 = 3.3 ± 0.5 mL/100 mL/min ;变化是可接受的小，表明建立正常的数据库的可行性<15>。每个受试者的CBF图像进一步空间归一化到标准Talairach坐标系使用SPM 99，和其他三个参数图像用相同的变换。该过程在标准坐标系中创建每个参数的平均正常图像，其可以以图像格式提供每个脑区域的正常值。

项目成果

H.Ito, M.Senda: "Database of normal human CBF, CBV, OEF, CMRO2, measured by PET."European Journal of Nuclear Medicine and Molecular Imaging. 31(5). 635-643 (2004)

H.Ito, M.Senda：“通过 PET 测量的正常人 CBF、CBV、OEF、CMRO2 数据库。”欧洲核医学和分子成像杂志。

H.Ito, M.Senda: "Normal database of CBF, CBV, OEF, CMRO2, measured by PET(抄録)"Journal of Nuclear Medicine. 43・5Suppl. 247 (2002)

H.Ito，M.Senda：“通过 PET 测量的 CBF、CBV、OEF、CMRO2 的正常数据库（摘要）”核医学杂志 43・5Suppl.247（2002 年）。

H.Ito, M.Senda: "Normal database of human CBF, CBV, OEF, CMRO2 measured by PET.抄録"Journal of Cerebral Blood Flow and Metabolism. 23 Suppl. 645 (2003)

H.Ito，M.Senda：“通过 PET 测量的人类 CBF、CBV、OEF、CMRO2 的正常数据库。摘要”脑血流和代谢杂志 23 Suppl。

H.Ito, M.Senda: "Database of normal human CBF, CBV, OEF, CMRO2, measured by PET."European Journal of Nuclear Medicine and Molecular Imaging. 31・5. 635-643 (2004)

H.Ito, M.Senda：“通过 PET 测量的正常人 CBF、CBV、OEF、CMRO2 的数据库”。欧洲核医学和分子成像杂志 31・5 (2004)。

H.Ito, M.Senda: "Normal database of human CBF, CBV, OEF, CMRO2measured by PET."Journal of Cerebral Blood Flow and Metabolism. 23 Suppl. 645 (2003)

H.Ito, M.Senda：“通过 PET 测量的人类 CBF、CBV、OEF、CMRO2 的正常数据库。”脑血流与代谢杂志。