Relation Between Neurotrophic Factor Related Gene And Minor Physical Anomalies(MPAs) in Japanese Patients with Schizophrenia

日本精神分裂症患者神经营养因子相关基因与轻微身体异常（MPA）的关系

• 批准号: 14570933
• 负责人: FUJIMARU Kosuke
• 金额: $ 2.24万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570933/
• 关键词: schizophrenia; minor physical anomalies; neurodevelopmental disorder; Waldrop scale; neurotrophic factor; BDNF; NT-3; CNTF; Waldrop Scale; Fyn; 高口蓋; 頭囲

In recent years, many investigators have proposed a neurodevelopmental hypothesis in schizophrenia. We assumed that minor physical anomalies (MPAs) were one indication of the neurodevelopmental disorder in the background of schizophrenia, and we analyzed the relationship between neurotrophic factor-related genes and MPAs in schizophrenia patients.We assessed the prevalence of MPAs in Japanese patients with schizophrenia (n = 313) and normal controls (n =128) using the Waldrop scale. There was a significant difference in the scale scores between the patients and control subjects (p = 0.02). Patients had significantly more MPAs than controls on the individual scale items of malformed ears (p = 0.039), furrowed tongue (p = 0.006), high steepled palate (p = 0.041) and head circumference which was 1.5 SDs below the average of normal controls (p=0.015). When we defined subjects at or above the median MPA score to be in the high anomaly group, significantly more patients than normal controls were represented in this group (p = 0.033).And we investigated the relationship between schizophrenia and neurotrophic factor-related genes, including brain-derived neurotrophic factor gene (BDNF), Neurotrophin-3 gene (NT-3), and the ciliary neurotrophic factor gene (CNTF).65 patients with schizophrenia were divided into groups based on their total MPAs score. There were 24 subjects in the low MPAs (2 or fewer) group and 41 subjects in the high MPAs (3 or more) group.Using the information acquired from the Genome Date Base about the three above-mentioned genes, we designed primers that amplified the range containing the polymorphism of dinucleotide repeats and administered PCR. We found 8, 9, and 4 alleles by BDNF, NT-3, and CNTF, respectively, and the distribution was similar to what is contained in the Genome Data Base. A comparison between the low MPAs group and high. MPAs group by each allele showed no significant differences.

近年来，许多研究者提出了精神分裂症的神经发育假说。本研究假设精神分裂症患者的轻微身体异常（Minor Physical Anteries，MPA）是神经发育障碍的一个指征，分析精神分裂症患者神经营养因子相关基因与MPA的关系，并采用Waldrop量表评估日本精神分裂症患者（n = 313）和正常对照组（n =128）中MPA的患病率。患者和对照组之间的量表评分有显著差异（p = 0.02）。在畸形耳（p = 0.039）、舌沟（p = 0.006）、高尖腭（p = 0.041）和头围（低于正常对照组平均值1.5 SD）的单个量表项目上，患者的MPA显著多于对照组（p=0.015）。当我们将处于或高于中位MPA评分的受试者定义为高异常组时，该组中的患者明显多于正常对照组（p = 0.033），并探讨了精神分裂症与神经营养因子相关基因的关系，包括脑源性神经营养因子基因（BDNF）、神经营养因子-3基因（NT-3）、和睫状神经营养因子基因（CNTF）的检测结果。低MPA（2个以下）组24例，高MPA（3个以上）组41例，利用从Genome Datasem获得的上述3个基因的信息，设计引物，扩增二核苷酸重复多态性的范围，进行PCR。BDNF、NT-3和CNTF分别检测到8、9和4个等位基因，其分布与基因组数据库中的分布相似。低MPA组与高MPA组之间的比较。MPAs组各等位基因差异无统计学意义。

项目成果

Minor-Physical Anomalies in Japanese Patients with Schizophrenia

日本精神分裂症患者的轻微身体异常

• 发表时间: 2002
• 期刊: Acta Medica Nagasakiensia Vol.47
• 作者: Kosuke Fujimaru;Akira Imamura;Takahiro Tsujita;Mayuko Uraguchi;Aoi Hashida;Takatoshi Mori;Sumitaka Matsumoto;Syunji Matsumoto;Yuji Okazaki;Yoshibumi Nakane
• 通讯作者: Yoshibumi Nakane

Minor physical anomalies

轻微的身体异常

• 发表时间: 2004
• 期刊: 臨床精神医学 第33巻(印刷中)
• 作者: 藤丸浩輔;岡崎祐士
• 通讯作者: 岡崎祐士

Minor Physical Anomalies in Japanese Patients with Schizophrenia

日本精神分裂症患者的轻微身体异常

• 发表时间: 2002
• 期刊: Acta Medica Nagasakiensia Vol.47
• 作者: Kosuke Fujimaru;Akira Imamura;Takahiro Tsujita;Mayuko Uraguchi;Aoi Hashida;Takatoshi Mori;Sumitaka Matsumoto;Syunji Matsumoto;Yuji Okazaki;Yoshibumi Nakane
• 通讯作者: Yoshibumi Nakane

Kosuke Fujimaru: "Minor Physical Anomalies in Japanese Patients with Schizophrenia"Acta Medica Nagasakiensia. Vol.47. 133-137 (2002)

Kosuke Fujimaru：“日本精神分裂症患者的轻微身体异常”Acta Medica Nagasakiensia。