The role of LOX-1 and oxidative stress in the progressive renal disease.

LOX-1 和氧化应激在进行性肾病中的作用。

• 批准号: 14571015
• 负责人: KANAME Shinya
• 金额: $ 2.24万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571015/
• 关键词: LOX-1; oxidative stress; 5; 6腎摘ラット

In this study, we investigated the LOX-1 expression 1in chronic renal failure model rats. 6 weeks after 5/6 nephrectomy, renal LOX-1 mRNA expression was markedly increased compared with control, which accompanied by elevation of blood pressure and impaired renal function. Immunohistochemical analysis showed that LOX-1 was widely expressed in the interstitial cells, although there was almost no staining in the glomeruli and tubules. Moreover, AT1 antagonist candesartan significantly suppressed the renal LOX-1 expression. These results suggest that enhanced renal expression of LOX-1 might play a role in the progression of chronic renal failure in rats.

在本研究中，我们研究了LOX-1在慢性肾功能衰竭模型大鼠中的表达。5/6肾切除术后6周，与对照组相比，肾LOX-1 mRNA表达明显升高，并伴有血压升高和肾功能受损。免疫组化分析显示LOX-1广泛表达于间质细胞，但在肾小球和小管中几乎没有染色。此外，AT1拮抗剂坎地沙坦显著抑制肾LOX-1的表达。这些结果提示，肾脏中LOX-1表达的增强可能在大鼠慢性肾功能衰竭的进展中起作用。

项目成果

Ueno T, Kaname S, Takaichi K, Nagase M, Tojo A, Onozato ML, Fujita T: "LOX-1, an oxidized low-density lipoprotein receptor, was upregulated in the kidneys of chronic renal failure rats."Hypertension Research. 26. 117-122 (2003)

Ueno T、Kaname S、Takaichi K、Nagase M、Tojo A、Onozato ML、Fujita T：“LOX-1，一种氧化的低密度脂蛋白受体，在慢性肾衰竭大鼠的肾脏中表达上调。”高血压研究。

Tomoko Ueno, Shinya Kaname, et al.: "LOX-1, an oxidized low-density lipoprote in recepror was upregulated in the kidneys of chronic renal failure rats"Hypertension Research. 26. 117-122 (2003)

Tomoko Ueno、Shinya Kaname 等人：“LOX-1（受体中的一种氧化低密度脂蛋白）在慢性肾衰竭大鼠的肾脏中表达上调”高血压研究。

Ueno T, Kaname S, Takaichi K, Nagase M, Tojo A, Onozato ML, Fujita T: "Lox-1, an oxidized low-density lipoprotein receptor, was upregulated in the kidneys of chronic renal failure rats."Hypertens Res. 26. 117-122 (2003)

Ueno T、Kaname S、Takaichi K、Nagase M、Tojo A、Onozato ML、Fujita T：“Lox-1，一种氧化的低密度脂蛋白受体，在慢性肾衰竭大鼠的肾脏中表达上调。”Hypertens Res。

Ueno T, Kaname S, et al.: "LOX-1 an oxidized low density lipoprotein receptor, was upregulated in the kidneys of chronic veval failure rats."Hypertens Res. 26. 117-122 (2003)

Ueno T、Kaname S 等人：“LOX-1 是一种氧化的低密度脂蛋白受体，在慢性肾衰竭大鼠的肾脏中表达上调。”Hypertens Res。