Auxiliary liver transplantation for fulminant hepatic failure-graft protection and native liver regeneration

辅助肝移植治疗暴发性肝衰竭——移植物保护和天然肝再生

• 批准号: 14571121
• 负责人: TAKADA Yasutsugu
• 金额: $ 2.24万
• 依托单位: KYOTO UNIVERSITY (2003)University of Tsukuba (2002)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571121/
• 关键词: fulminant hepatic failure; auxiliary liver transplantation; cytokine; liver regeneration; pig liver transplantation; 肝移植

'Toxic liver syndrome' can lead to considerable morbidity and mortality in some clinical cases of auxiliary partial orthotopic liver transplantation (APOLT) against fulminant hepatic failure (FHF). After inducing FHF to male pigs by the administrarion of alpha-amanitin and lipopolysaccharide, all of the pigs died within 5 days with clinically relevant features of FHF. Pigs under the same condition were rescued by APOLT 8 hours after induction of FHF. When the timing of APOLT was 24 hours after toxin injection, none of the pigs could survive more than 5 days.Additional treatment with a novel potent cytokine suppressor 'ONO-SM-362' to APOLT prolonged the survival time of these pigs more than 2 weeks. Controlling cytokines being released from necrotic native liver is important to obtain good results of APOLT against FHF.

“中毒性肝综合征”可导致某些临床病例中的辅助性部分原位肝移植（APOLT）治疗暴发性肝功能衰竭（FHF）的相当高的发病率和死亡率。用α-鹅膏蕈碱和脂多糖诱导雄性猪发生FHF后，所有猪均在5天内死亡，具有FHF的临床相关特征。诱导FHF后8小时，在相同条件下通过APOLT拯救猪。注射毒素后24小时再注射APOLT，无猪存活超过5天，用新型细胞因子抑制剂“ONO-SM-362”治疗APOLT，可使存活时间延长2周以上。控制坏死的自体肝释放细胞因子是APOLT治疗FHF获得良好效果的重要因素。

项目成果

Takada Y: "Rapid and aggressive recurrence accompanied by portal tumor thrombus after radiofrequency ablation for hepatocellular carcinoma."Int J Clin Oncol. 8. 332-335 (2003)

Takada Y：“肝细胞癌射频消融后，快速、侵袭性复发并伴有门静脉癌栓。”Int J Clin Oncol。

Takada Y et al.: "Large-animal models of fulminant hepatic failure"J Artif Organs. 6. (2003)

Takada Y 等人：“暴发性肝衰竭的大型动物模型”J Artif Organs。

"Large animal models for transplantation Research. -Atlas of Experimental Surgery."Nippon Igakukan.

“用于移植研究的大型动物模型。-实验外科地图集。”日本医学馆。

Takada Y: "Large animal models of fulminant hepatic failure."J Artif Organs. 6. 9-13 (2003)

Takada Y：“暴发性肝衰竭的大型动物模型。”J Artif Organs。

Ishiguro S: "Auxiliary partial orthotopic liver transplantation for fulminant hepatitis - regeneration of the diseased native liver in a pig model."Transplantation. 75. 1901-1904 (2003)

Ishiguro S：“针对暴发性肝炎的辅助部分原位肝移植——猪模型中患病的天然肝脏的再生。”移植。