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The Optimum Tensile Strength in Rotator Cuff Repair in Rats

大鼠肩袖修复的最佳拉伸强度

基本信息

批准号：
14571356
负责人：
ITOI Eiji
金额：
$ 1.09万
依托单位：
Akita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

We performed this experimental study to clarify the optimum t ensile strength in rotator cuff repair. We used 160 SD rats/320 shoulders. On the right side, 2 mm of supraspinatus tendon defect was created, opposite side was sham operated as control. Rotator Cuffs were repaired 8 categories of initial tensile strength (0g, 50g, 100g, 150g, 200g, 250g, and 300g).Specimens were obtained, 3 days, 1 week, 3 weeks, and 6weeks after the operation. Muscle volume of the supraspinatus, minor axis of muscle fibers, cell number in collagen fiber, configuration of collagen fiber were measured histologically, and maximum load, cross sectional area of the time, and maximum stress were assessed biomechanically.The volume of supraspinatus decreased postoperatively. Significant difference was not fount between repaired groups and controls. Initial tensile strength in cuff repair was not influent to the Amyotrophy of supraspinatus. Increase of round cell in collagen fiber was observed and collagen fiber was disheveled in comparison with a group of control where the supraspinatus tendon retouched. In cases that initial tensile strength was small, disorder of collagen fiber was large at 3 weeks postoperatively. However thes e no difference as compared with controls 6 weeks after the repair. The capillary neogenesis revealed no difference compared with control. Maximal loads at the sixth week were largest in 200g group. Maximum load of this group was significant greater than 0g, 50g groups.In conclusion, existence of optimum tension in rotator cuff repair was suggested. In the present experiment, 200g neighborhood can be said to be optimal tension.

我们进行了这项实验研究，以澄清最佳的拉伸强度在肩袖修复。SD大鼠160只/320肩。右侧造成冈上肌腱缺损2 mm，对侧假手术作为对照。将肩袖按初始抗拉强度分为0 g、50 g、100 g、150 g、200 g、250 g、300 g 8个等级，分别于术后3d、1周、3周、6周取材。组织学测量冈上肌体积、肌纤维短轴、胶原纤维细胞数、胶原纤维形态，生物力学测量最大负荷、时间横截面积、最大应力。修复组与对照组之间无显著性差异。肩袖修复的初始抗张强度对冈上肌萎缩无影响。冈上肌腱修复组胶原纤维中圆形细胞增多，胶原纤维排列紊乱。初始抗张强度小的病例，术后3周胶原纤维排列紊乱严重。修复后6周与对照组比较无显著性差异。毛细血管新生与对照组无明显差异。200 g组第6周最大负荷最大。最大负荷明显大于0 g、50 g组，提示肩袖修复存在最佳张力。在本实验中，200 g附近可以说是最佳张力。