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Crosstalk from energy regulating system to female reproductive system

从能量调节系统到女性生殖系统的串扰

基本信息

批准号：
14571566
负责人：
MATSUZAKI Toshiya
金额：
$ 2.11万
依托单位：
The University of Tokushima
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571566/
关键词：
orexinergic peptides orexin ghrelin GnRH LH leptin reptin receptor 摂食調節因子 βエンドルフィン

项目摘要

Reproductive system is affected by energy regulating system. Starvation weight loss easilys amenorrhea in women. Recently, several factors which regulate appetite are discovered. We studied crosstalk of these factors toward female reproductive system. Our findings are as follows.1.Acute cerebroventricular injection of Ghrelin suppressed pulsatile LH secretion in ovariectomized rat, and this phenomenon was cancelled by co-administration of naroxon. Ghrelin suppressed GnRH srelease via beta-endorphine.2.Acute cerebroventricular injection of Orexin-A suppressed pulsatile LH secretion, and this phenomenon was cancelled by co-administration of naroxon or NPY antibody. Orexin-A suppressed GnRH srelease via beta-endorphine and NPY.Orexin-A suppressed pulsatile GnRH secretion via beta-endorphine and NPY in ovariectomized rat.3.Chronic intracerevro-ventricullar injection of Ghrelin or Orexin-A accelerated food intake and weight gain in mature female rats, however estrus cycle was not influenced … More at all. Hypothalamic orexinergic peptide such as ghrelin and orexin-A seemed not to have sufficient inhibitory action to induce anovulation. In weight loss and amenorrheic situation, many signals which control energy homeostasis including hypothalamic orexinergic peptides and peripheral originated circulating leptin would be integrated and work together to stop ovulation.4.Leptin stimulated gonadotropin secretion in juvenile rat pituitary cells, and suitable leptin concentration for this stimulatory effect shifed in accordance with development ; Juvenile rat pituitary was more sensitive to leptin than latter ages. Messenger RNA of functional leptin receptor(OB-Rb) was highly expressed at juvenile age compared with latter ages in female rats pituitary. On the other hand, serum leptin concentration increased though pubertal development in contrast to OB-Rb mRNA expression in the pituitary. In conclusion, juvenile female rat pituitary might be sensitive to the increase of serum leptin concentration preparing puberty. Less

生殖系统受能量调节系统的影响。饥饿减肥容易导致女性闭经。最近，人们发现了几个调节食欲的因素。我们研究了这些因素对女性生殖系统的影响。我们的研究结果如下。急性脑室注射Ghrelin抑制去卵巢大鼠脉动性LH分泌，同时给药naroxon可消除这一现象。Ghrelin通过-内啡肽抑制GnRH的释放。急性脑室注射Orexin-A可抑制脉动性LH分泌，同时给药naroxon或NPY抗体可消除这种现象。Orexin-A通过β -内啡肽和NPY抑制GnRH释放。Orexin-A通过β -内啡肽和NPY抑制去卵巢大鼠脉动性GnRH分泌。慢性脑室内注射Ghrelin或Orexin-A加速了成熟雌性大鼠的食物摄入和体重增加，但对发情周期没有影响。下丘脑食欲能肽如胃饥饿素和食欲素- a似乎没有足够的抑制作用来诱导无排卵。在体重减轻和闭经的情况下，控制能量稳态的许多信号，包括下丘脑的食欲能肽和外周来源的循环瘦素，将被整合并共同作用，以停止排卵。瘦素刺激幼年大鼠垂体细胞促性腺激素分泌，且适合瘦素浓度随发育变化而变化；幼年大鼠垂体对瘦素的敏感性高于老年大鼠。雌性大鼠垂体功能性瘦素受体（OB-Rb）信使RNA在幼年期较老年期高表达。另一方面，与垂体OB-Rb mRNA表达相反，血清瘦素浓度通过青春期发育而增加。综上所述，幼年雌性大鼠垂体可能对血清瘦素浓度的升高敏感。少