the effect of the growth factor and the anti-caspase 3 to the olfactory epithelium

嗅觉上皮的独特之处在于它能够产生新的感觉神经元，并在一生中通过细胞凋亡而消失。我们认为，随着年龄的增长，嗅觉功能的恶化是由于嗅觉上皮细胞随着年龄的增长而萎缩，这种萎缩与细胞增殖减少和细胞凋亡增加有关。基底层可见大量隧道阳性细胞。对衰老小鼠嗅觉上皮细胞的影响。而成年小鼠的基底层仅有少量隧道阳性细胞。我认为，嗅觉上皮细胞凋亡的增加导致了嗅觉上皮细胞的萎缩。在给予大剂量糖皮质激素的小鼠嗅觉上皮细胞的基底层出现了一些隧道阳性细胞。而对照组小鼠嗅觉上皮细胞仅有少量隧道阳性细胞，我认为大剂量糖皮质激素可促进嗅觉上皮细胞的凋亡。在给予秋水仙碱和抗caspase 3的小鼠嗅觉上皮细胞中仅有少量隧道阳性细胞，而在仅给予秋水仙碱的小鼠嗅觉上皮细胞中出现大量隧道阳性细胞。我认为抗caspase3抑制了嗅觉上皮细胞的凋亡。

The olfactory epithelium is unique in its ability to give rise to new sensory neurons and to drop out by apoptosis throughout about life We believe that the deterioration of olfactory function with aging derives from atrophy of the olfactory epitheliurn with aging, and that this atrophy is related to a decrease in cell proliferation and to a increase in apoptosis. Many tunnel-positive cells occurred in the basal layers. of the olfactory epithelium in the aged mouse. However only few tunnel-positive cells occurred in the basal layer of adult mouse. I think that a increase in appoptosis in the olfactory epithelium induces the atrophy of the olfactory epithelium.Some tunnel-positive cells occurred in the basal layers of the olfactory epithelium in the mouse which-is given high dose glucocorticoid. However only few tunnel-positive cells occurred in the basal layer of the control mouse.I think that high-dose glucocorticoid promotes the apoptosis of olfactory epithelium.Only a few tunnel-positive cells occurred in the olfactory epithelium of the mouse which is given colchicines and anti-caspase 3. However many tunnel-positive cells occurred in the olfactory epithelium of the mouse which is given only colchicines. I think that anti-caspase 3 suppresses the apoptosis of olfactory epithelium.