Evaluation of Autogenous Iliac Bone Grafting for Alveolar Cleft of Cleft Lip and Palate Patients-Use of Platelet Rich Plasma(PRP)-

对18例唇腭裂患者术后植骨情况进行了观察（18例）在牙槽突裂中使用富血小板血浆（PRP）进行髂骨移植（PRP组），并与17例唇腭裂患者进行比较（17例裂）在没有PRP的情况下接受移植术后1周、1个月、3个月和6个月，测量牙槽突裂骨桥上、下缘的水平。根据铝当量（Al-Eq）值测量牙科X线片上的骨密度，其中铝当量（Al-Eq）值基于将厚度为0至16 mm的铝楔安装在胶片保持器上。术后6个月，当骨桥上缘水平≤ 1.0，下缘水平≥ 3.0时，手术结果被视为良好，否则被视为失败。并进行了评估， ...更多信息 两组。结果表明：（1）术前血浆血小板平均数为27.7×10^4/μl，PRP血小板平均数为86.8×10^4/μl，浓缩率为319.9%。PRP组术后3个月Al-Eq迅速下降，6个月略有上升。在非PRP组中，Al-Eq在术后6个月逐渐降低。PRP组的骨再生速度略快于非PRP组。3.术后1周至3个月，PRP组和非PRP组骨桥下缘均略有减少，但差异无统计学意义。两组骨桥上缘在术后1个月内迅速吸收，然后几乎保持不变。PRP组9例患者中有7例在术后6个月观察到良好结局（77.8%），非PRP组17例患者中有9例（52.9%）。4.术后1周至6个月骨桥宽度变化率PRP组为77.2%，非PRP组为71.7%，结果表明，PRP可促进自体髂骨的骨再生，从而使髂骨移植获得良好的效果。少

The postoperative changes in the grafting bone were evaluated in 18 patients with cleft lip and palate (18 clefts) who had undergone iliac bone grafting in the alveolar cleft using platelet rich plasma(PRP)(PRP group), and compared to those in 17 patients with cleft lip and palate (17 clefts) who had undergone grafting without PRP (non-PRP group).Dental X-ray with an aluminum wedge was taken in the grafted bone in the alveolar cleft, 1 week, and 1,3,and 6 months postoperatively, and the levels of the upper and lower margins of the bone bridge in the alveolar cleft was measured. The bone density on the dental X-ray film was also measured on an aluminum-equivalence(Al-Eq) value based on aluminum wedge with a thickness of 0 to 16 mm was mounted on the film holder.The surgical outcome was regarded as good when the level of the upper margin of the bone bridge was 1.0 or less and that of the lower margin was 3.0 or more 6 months postoperatively and as failure otherwise, and was evaluated on … More both groups. The results were as follows :1.Preoperatively, the mean number of platelets in the plasma was 27.7×10^4/μl, and that in the PRP was 86.8×10^4/μl, showing a concentration rate of 319.9%. It was confirmed that the number of platelets in the PRP were increased.2.The Al-Eq rapidly decreased up to 3 months postoperatively in the PRP group, and slightly increased 6 months postoperatively. In the non-PRP group, the Al-Eq gradually decreased up to 6 months postoperatively. Bone regeneration was slightly more rapid in the PRP group than in the non-PRP group.3.The lower margin of the bone bridge was slightly decreased from 1 week to 3 months postoperatively in the PRP and non-PRP groups, but the differences were not significant. The upper margin of the bone bridge was rapidly absorbed up to 1 month postoperatively in both groups, and then remained almost unchanged. Good outcomes 6 months postoperatively were observed in 7 of the 9 patients in the PRP group(77.8%), and in 9 of the 17 patients in the non-PRP group(52.9%).4.The rate of change in the bone bridge width between 1 week and 6 months postoperatively was 77.2% in the PRP group and 71.7% in the non-PRP group, indicating that bone absorption was slightly lower in the former than in the latter.These findings suggested that PRP enhanced bone regeneration by acting on the autogenous iliac bone, resulting in good outcomes of iliac bone grafting. Less