DECIPHERING THE ORIGIN OF MAGNETITE IN HUMAN BRAIN TISSUE
破译人类脑组织中磁铁矿的起源
基本信息
- 批准号:470880236
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:
- 资助国家:德国
- 起止时间:
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Animals from several phyla are thought to detect the magnetic field and use it to their advantage. The most compelling example comes from magnetotactic bacteria that contain single domain (ca. 40-200 nm) magnetite (Fe3O4) or greigite (Fe3S4) crystals, called magnetosomes. Magnetosomes are fixed within the cell that compel the bacteria to swim along magnetic field lines. Interestingly, human brain tissue contains magnetite crystals that have identical morphologies as those found in some magnetotactic bacteria. Our previous work showed a systematic distribution of single domain magnetite in seven dissected, entire post mortem human brains suggesting the body internally biomineralizes the iron oxide. Other studies have reported much smaller (< 40 nm, superparamagnetic) magnetite in human brain tissue and suggested the superparamagnetic magnetite originates from external sources. This proposal aims to determine the properties, concentrations and the origin of both single domain and superparamagnetic magnetite particles in the human brain. We wish to further test whether a difference exists in magnetic characteristics between formalin-fixed tissue and fresh-frozen tissue. We propose to apply unique magnetic methods that will map the relative grain size and chemical composition of the magnetite as well as determine the spatial orientation (anisotropy) of the magnetite crystals in human brains. Systematic distribution in magnetite grain size, magnetite chemistry and/or geometric construction (anisotropy) would constitute groundbreaking evidence to determine the origin of magnetite in the human brain. If the magnetite is indeed shown to have a biogenic origin, then understanding its function in subsequent research should lead to important advances in human brain studies. If environmental, then understanding how the particles enter and become stored in the brain and their reactivity in physiological conditions will likewise have a huge impact on future research.
来自几个门的动物被认为能探测到磁场并利用它来为自己谋利。最引人注目的例子来自含有单结构域的趋磁细菌(约。40-200 nm)的磁铁矿(Fe 3 O 4)或硫铁矿(Fe 3S 4)晶体,称为磁小体。磁小体固定在细胞内,迫使细菌沿着磁场线游动。有趣的是,人脑组织中含有磁铁矿晶体,其形态与某些趋磁细菌中发现的相同。我们以前的工作表明,在七个解剖的,整个死后人脑单域磁铁矿的系统分布,这表明身体内部的氧化铁生物矿化。其他研究报告了人脑组织中更小的(< 40 nm,超顺磁性)磁铁矿,并建议超顺磁性磁铁矿来自外部来源。该建议旨在确定人脑中单畴和超顺磁性磁铁矿颗粒的性质、浓度和来源。我们希望进一步测试福尔马林固定的组织和新鲜冷冻的组织之间的磁特性是否存在差异。我们建议应用独特的磁性方法,将映射的相对晶粒大小和化学成分的磁铁矿,以及确定的空间取向(各向异性)的磁铁矿晶体在人脑中。磁铁矿粒度、磁铁矿化学和/或几何构造(各向异性)的系统分布将构成确定人脑中磁铁矿起源的突破性证据。如果磁铁矿确实被证明具有生物起源,那么在随后的研究中了解其功能应该会导致人类大脑研究的重要进展。如果是环境因素,那么了解这些粒子如何进入并储存在大脑中,以及它们在生理条件下的反应性,也将对未来的研究产生巨大的影响。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Professor Dr. Stuart Alan Gilder其他文献
Professor Dr. Stuart Alan Gilder的其他文献
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{{ truncateString('Professor Dr. Stuart Alan Gilder', 18)}}的其他基金
Magnetic properties and microfabrics of shocked minerals and their influence on the magnetic anomalies in the Ries, Vredefort and Manicouagan impact structures
冲击矿物的磁特性和微结构及其对 Ries、Vredefort 和 Manicouagan 冲击构造磁异常的影响
- 批准号:
433311356 - 财政年份:2019
- 资助金额:
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Research Grants
The Neoproterozoic geomagnetic field: New insights from a high-resolution paleomagnetic study in South China
新元古代地磁场:华南高分辨率古地磁研究的新见解
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413587100 - 财政年份:2018
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Distinguishing detrital versus chemical remanent magnetization in sediments: Toward a better understanding of relative paleointensity records
区分沉积物中的碎屑与化学剩磁:更好地理解相对古强度记录
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389869201 - 财政年份:2017
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Changes in paleo-erosion rates, and interactions between erosion, deposition and deformation in the Issyk Kul basin, Kyrgyzstan
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- 批准号:
273969534 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Research Grants
Do meteorite impacts the geomagnetic field and can meteorites retain the record of planetary magnetic fields?
陨石是否会影响地磁场?陨石能否保留行星磁场的记录?
- 批准号:
169945988 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Priority Programmes
How pressure influences the magnetic properties of titanomagnetite and iron with implications for magnetic anomalies and core fields
压力如何影响钛磁铁矿和铁的磁性,并对磁异常和核心场产生影响
- 批准号:
170001569 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Priority Programmes
Understanding magnetic remanence acquisition in sediments through a combined experimental and numerical approach
通过实验和数值相结合的方法了解沉积物中剩磁的采集
- 批准号:
98959802 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Research Grants
Toward a better understanding of the Cretaceous geomagnetic polarity superchron via paleosecular variation studies at the Earth's equator
通过地球赤道的古世变研究更好地了解白垩纪地磁极性超纪元
- 批准号:
58141235 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Research Grants
To understand how continental sediments acquire their magnetic records through automized remanence anisotropy experiments
了解大陆沉积物如何通过自动剩磁各向异性实验获取磁记录
- 批准号:
49045840 - 财政年份:2007
- 资助金额:
-- - 项目类别:
Research Grants
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