Novel anti-atherosclerotic and anti-thrombotic action of plasma heparin cofactor II

血浆肝素辅因子 II 的新型抗动脉粥样硬化和抗血栓形成作用

• 批准号: 16590692
• 负责人: AZUMA Hiroyuki
• 金额: $ 1.98万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590692/
• 关键词: thrombin; heparin cofactor II; atherosclerosis; coronary intervention; knockout mice; vascular remodeling; vascular smooth muscle cell; thrombin receptor; PCI; PAR

HCII+/- mice we generated had about 60% of plasma HCII activity. Cuff placement around femoral artery for 4 weeks caused prominent neointimal and adventitial hyperplasia with augmented expression of protease-activated receptor 1 in HCII+/- mice compared with HCII+/+ mice. These exacerbated vascular remodeling was ameliorated to similar level as HCII+/+ mice by administration of purified human HCII protein.

我们建立的HCII+/-小鼠具有大约60%的血浆HCII活性。在股动脉周围放置袖带4周后，HCII+/-小鼠较HCII+/+小鼠出现明显的新生内膜和外膜增生，其蛋白水解酶激活受体1的表达增强。通过给予纯化的人HCII蛋白，这些加剧的血管重塑被改善到与HCII+/+小鼠相似的水平。

项目成果

Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression.

• DOI: 10.1016/j.atherosclerosis.2005.03.003
• 发表时间: 2005-11
• 期刊: Atherosclerosis
• 影响因子: 5.3
• 作者: Midori Kato;H. Azuma;M. Akaike;Takahiko Iuchi;K. Aihara;Yasumasa Ikeda;M. Fujimura;Tomonori Yoshida;H. Yamaguchi;Shunji Hashizume;Toshio Matsumoto

Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat carotid artery.

• DOI: 10.1016/j.atherosclerosis.2004.08.029
• 发表时间: 2005
• 期刊: Atherosclerosis
• 影响因子: 5.3
• 作者: Tomonori Yoshida;H. Azuma;K. Aihara;M. Fujimura;M. Akaike;T. Mitsui;Toshio Matsumoto

Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis

• DOI: 10.1074/jbc.m411694200
• 发表时间: 2005-08-19
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Ikeda, Y;Aihara, K;Matsumoto, T
• 通讯作者: Matsumoto, T

Heparin cofactor II is a novel protective factor against carotid atherosclerosis in elderly individuals

• DOI: 10.1161/01.cir.0000129968.46095.f3
• 发表时间: 2004-06-08
• 期刊: CIRCULATION
• 影响因子: 37.8
• 作者: Aihara, K;Azuma, H;Matsumoto, T
• 通讯作者: Matsumoto, T

High plasma heparin cofactor II activity is associated with reduced incidence of in-stent restenosis after percutaneous coronary intervention

• DOI: 10.1161/01.cir.0000109695.39671.37
• 发表时间: 2004-02-03
• 期刊: CIRCULATION
• 影响因子: 37.8
• 作者: Takamori, N;Azuma, H;Matsumoto, T
• 通讯作者: Matsumoto, T