Novel anti-atherosclerotic and anti-thrombotic action of plasma heparin cofactor II
Novel anti-atherosclerotic and anti-thrombotic action of plasma heparin cofactor II
批准号:
16590692
负责人:
AZUMA Hiroyuki
金额:
$1.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2004
资助国家:
日本
项目状态:
已结题
起止时间:
2004 至 2005
中文摘要
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英文摘要
HCII+/- mice we generated had about 60% of plasma HCII activity. Cuff placement around femoral artery for 4 weeks caused prominent neointimal and adventitial hyperplasia with augmented expression of protease-activated receptor 1 in HCII+/- mice compared with HCII+/+ mice. These exacerbated vascular remodeling was ameliorated to similar level as HCII+/+ mice by administration of purified human HCII protein.
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DOI:
10.1016/j.atherosclerosis.2005.03.003
发表时间:
2005-11
期刊:
Atherosclerosis
影响因子:
5.3
作者:
[Midori Kato;H. Azuma;M. Akaike;Takahiko Iuchi;K. Aihara;Yasumasa Ikeda;M. Fujimura;Tomonori Yoshida;H. Yamaguchi;Shunji Hashizume;Toshio Matsumoto]
通讯作者:
Midori Kato;H. Azuma;M. Akaike;Takahiko Iuchi;K. Aihara;Yasumasa Ikeda;M. Fujimura;Tomonori Yoshida;H. Yamaguchi;Shunji Hashizume;Toshio Matsumoto
DOI:
10.1016/j.atherosclerosis.2004.08.029
发表时间:
2005
期刊:
Atherosclerosis
影响因子:
5.3
作者:
[Tomonori Yoshida;H. Azuma;K. Aihara;M. Fujimura;M. Akaike;T. Mitsui;Toshio Matsumoto]
通讯作者:
Tomonori Yoshida;H. Azuma;K. Aihara;M. Fujimura;M. Akaike;T. Mitsui;Toshio Matsumoto
DOI:
10.1074/jbc.m411694200
发表时间:
2005-08-19
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Ikeda, Y, Aihara, K, Matsumoto, T]
通讯作者:
Matsumoto, T
DOI:
10.1161/01.cir.0000129968.46095.f3
发表时间:
2004-06-08
期刊:
CIRCULATION
影响因子:
37.8
作者:
[Aihara, K, Azuma, H, Matsumoto, T]
通讯作者:
Matsumoto, T
DOI:
10.1161/01.cir.0000109695.39671.37
发表时间:
2004-02-03
期刊:
CIRCULATION
影响因子:
37.8
作者:
[Takamori, N, Azuma, H, Matsumoto, T]
通讯作者:
Matsumoto, T
Role and clinical significance of heparin cofactor II as an anti-atherosclerotic factor
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批准号:11838011
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:1999
-
负责人:AZUMA Hiroyuki
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依托单位:
Elucidation of genetic abnormality and molecular pathogenesis of hereditary hemorrhagic telangiectasia
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批准号:09671117
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:1997
-
负责人:AZUMA Hiroyuki
-
依托单位:
Development of urtrasensitive noncompetitive enzyme immunoassay for hypothalamic hormone and it's clinical application
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批准号:04671485
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1992
-
负责人:AZUMA Hiroyuki
-
依托单位:
海外基金