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MEG and rTMS study on the pathology and new treatment for, auditory hallucination in schizophrenia

MEG和rTMS对精神分裂症幻听病理学及新疗法的研究

基本信息

批准号：
16591134
负责人：
ISHII Ryouhei
金额：
$ 2.18万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

In this study, we compared EEG, MEG and SPECT findings before and after rTMS sessions for seven cases of chronic pain. The EEG and MEG findings improved among all patients despite the improvement of pain symptoms. On the other hands, the SPECT findings improved among only the patients who showed the improved symptoms. These results suggest that the electrophysioloical methods like EEG and MEG might be more sensitive than rCBF methods like SPECT. Our future application would be the evaluation of correlation between-several stimulus conditions of rTMS and the electrophysioloical methods like EEG and MEG.Using a spatially filtered magnetoencephalography analysis (SAM), we estimated neural activations in the Stroop task in nearly real time for schizophrenic patients with/without auditory hallucinations and for normal control subjects. In addition, auditory hallucinations were examined through the information processing flow of the brain neural network, including the frontal regions. In the 25-60-Hz band, cortical regions that showed significant current source density changes were examined for each time window. The three groups showed significantly decreased current source density, corresponding to neural activation, with temporal overlap along the fundamental cognitive information processing flow: sensory input system, executive control system, motor output system. Transient neural activations in the dorsolateral prefrontal cortex were bilateral with left-side dominancy for normal controls, left-lateralized for nonhallucinators and right-lateralized for hallucinators. Our results suggest that the dysfunction in the left dorsolateral prefrontal cortex was related to auditory hallucinations, while the information processing flow was unaffected in the schizophrenic subjects in the Stroop task.

在这项研究中，我们比较了EEG，MEG和SPECT的结果之前和之后的rTMS会议为7例慢性疼痛。尽管疼痛症状有所改善，但所有患者的EEG和MEG结果均有所改善。另一方面，SPECT结果仅在症状改善的患者中有所改善。这些结果表明，EEG和MEG等电生理方法可能比SPECT等rCBF方法更敏感。我们未来的应用将是评估rTMS的几个刺激条件之间的相关性和电生理方法，如EEG和MEG.Using空间滤波脑磁图分析（SAM），我们估计神经激活的Stroop任务在近真实的时间的精神分裂症患者/无幻听和正常对照组。此外，通过大脑神经网络（包括额叶）的信息处理流程检查幻听。在25-60-Hz频带中，在每个时间窗检查显示显著电流源密度变化的皮质区域。三组均表现出显著降低的电流源密度，对应于神经激活，沿着基本的认知信息处理流程：感觉输入系统，执行控制系统，运动输出系统的时间重叠。在背外侧前额叶皮层的瞬时神经激活是双边的左侧优势正常对照组，左侧的nonhallucinators和右侧的hallucinators。我们的研究结果表明，左背外侧前额叶皮层的功能障碍与幻听有关，而在Stroop任务中，精神分裂症受试者的信息处理流程不受影响。