Usefulness of combination of magnetization transfer ratios and proton MR spectroscopy in patients with chronic cerebro-vascular disease ; a comparative study with PET images

磁化转移比和质子磁共振波谱相结合对慢性脑血管疾病患者的有用性；

• 批准号: 16591238
• 负责人: KADO Hirotsugu
• 金额: $ 1.86万
• 依托单位: Research Institute for Brain and Blood Vessels -Akita (Research Bureau)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591238/
• 关键词: MTR; PET; MRS; Chronic brain ischemia; MRI

Purpose : 1)To assess the usefulness of combination of magnetization transfer ratio (MTR) and MR spectroscopy (MRS) technique in the ischemic brain tissue, from a point of view of prognosis, treatment and management. 2)To clarify the relationship between the values of MTR and MRS data, based on the values of PET parameters for gold standard.Methods : Using MR and PET machines, ischemic areas in brain tissue were investigated in 15 patients with unilateral ICA and MCA occlusion. Within 6 hours after magnetization transfer images (MTI) acquisition and MRS measurement by MR machine, cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2) and oxygen extraction fraction (OEF) images were obtained by PET machine in the same patients. The ischemic areas of brain tissue were classified into 3 groups (mild, moderate and severe) based on PET parameters. In each group, the relationship between MTR and MRS data was analyzed, and the relationship between PET parameters and MRS indexes … More was also reviewed.Results : Individuals in the normal group revealed normal values of NAA/Cr, Cho/Cr and MTR. In the mild and moderate ischemic group, having reversible ischemia by PET study, the areas were characterized by normal NAA/Cr, normal MTR and normal Cho/Cr. Although the Cho/Cr values showed wide ranges, the Cho/Cr values in the areas of moderate ischemia revealed higher than those in the areas of mild ischemia. In severe ischemic group, having irreversible ischemia, decreased NAA/Cr, increased Cho/Cr, and reduced MTR were found. A significant correlation between the values of MTR and that of CMRO2 was found, a correlation between the values of CMRO2 and that of NAA/Cr was also discovered.Conclusion : The combination of MTR and MRS methods became feasible for classifying the ischemic areas into 3 groups, as well as in classifying the PET parameters. The values of CMRO2 correlated significantly with that of NAA/Cr and MTR. The combination of MTR and MRS was useful for assessment of hemodynamic status. Less

目的：1）从预后、治疗和管理的角度评价磁化传递率（MTR）和磁共振波谱（MRS）技术在缺血脑组织中的应用价值。2）以PET参数值为金标准，探讨MTR值与MRS值之间的关系方法：对15例单侧伊卡和MCA闭塞的患者，分别用MR和PET机对脑组织缺血区进行检查。磁共振成像（MRI）采集磁共振图像（MTI）和磁共振波谱（MRS）测量后6 h内，用PET扫描仪测量脑血流量（CBF）、脑氧代谢率（CMRO 2）和氧摄取分数（OEF）。根据PET参数将脑组织缺血区分为轻度、中度和重度3组。分析各组MTR与MRS数据之间的关系，以及PET参数与MRS指标之间的关系 ...更多信息 结果：正常组NAA/Cr、Cho/Cr、MTR均正常。轻、中度脑缺血组，PET检查为可逆性脑缺血，其NAA/Cr、MTR、Cho/Cr均正常。虽然Cho/Cr值显示了较宽的范围，但中度缺血区的Cho/Cr值高于轻度缺血区。重度缺血组出现不可逆性缺血，NAA/Cr降低，Cho/Cr升高，MTR降低，MTR与CMRO 2、CMRO 2与NAA/Cr相关。MTR和MRS方法的组合对于将缺血区域分为3组以及对PET参数进行分类变得可行。CMRO 2与NAA/Cr、MTR呈显著正相关。MTR和MRS联合应用可用于评价血流动力学状态。少

项目成果

Depressive psychosis : clinical usefulness of MR spectroscopy data in predicting prognosis

抑郁性精神病：磁共振波谱数据在预测预后中的临床用途

• 发表时间: 2006
• 期刊: Radiology 238(1)
• 作者: K.Miyata;T.Hasegawa;et al.;Hirotsugu Kado
• 通讯作者: Hirotsugu Kado