A new approach of intra-operative real time diagnosis of metastasis by positron probe in gastroenterological carcinomas

正电子探针术中实时诊断胃肠癌转移的新方法

• 批准号: 16591312
• 负责人: YASUDA Takushi
• 金额: $ 2.3万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591312/
• 关键词: positron probe; FDG guided surgery; intra-operative real time diagnosis; positron probe; coincidence probe

(1)Development of positron probe for intra-operative applicationApollomec corporation developed positron probe with two types of detectors, plastic scintillator for beta rays and BGO crystal for gamma rays. This probe counts as a real event only when both rays are detected simultaneously in order to reduce background level.(2)Committee on clinical application of radioisotopeOur protocol in clinical application is planned to measure radioactivity by positron probe during operation after injection of ^<18>F-FDG in P3 room just before operation. Therefore, the influence to the human body of ^<18>F was evaluated in above-mentioned committee. As a result, the committee approved the usage of ^<18>F, because that half life is very short and the influence to the human body is very little.(3)Examination of injection time of ^<18>F-FDGAs a matter of fact, to delay to start operation is needed to inject ^<18>F-FDG just before operation, because it takes a time to synthesize and purify ^<18>F-FDG. Therefore, we examined whether radioactivity of ^<18>F could be measured or not when ^<18>F-FDG was injected in the evening of the day before operation. The half life of ^<18>F is 109.8 minute. Theoretically, radioactivity is reduced to about 1/256, assuming to measure after 16 hours of injection. We measured radioactivity by gamma probe next morning in patients of esophageal squamous cell carcinoma with huge lymph node metastasis, however, its count was very subtle, so that this protocol of previous day injection was found not to be clinically applicable. Above all, the necessity of injection of ^<18>F-FDG just before operation was suggested to maintain diagnostic quality and accuracy by positron probe.Conclusion : A lot of issues to have to be resolved are still remained, however, FDG-guided surgery may be the promising new approach to have a potential as a breakthrough of quality of surgery.

(1)开发用于术中应用的正电子探针Apollomec公司开发了具有两种类型探测器的正电子探针，用于β射线的塑料闪烁体和用于γ射线的BGO晶体。只有同时检测到两条射线时，该探针才算作真实事件，以降低背景水平。(2)放射性同位素临床应用委员会我们的临床应用方案计划在手术前在P3室注射^18F-FDG后，在手术期间通过正电子探针测量放射性。因此，在上述委员会中评价了^ 18 F对人体的影响。因此，委员会批准了^<18>F的使用，因为^<18>F的半衰期很短，对人体的影响很小。(3)^<18>F-FDGA注射时间的检查事实上，为了延迟开始手术，需要在术前注射^<18>F-FDG，因为^<18>F-FDG的合成和纯化需要时间。因此，我们检查了术前一天晚上注射^ 18 F-FDG时是否可以测量^ 18 F的放射性。 ^ 18 F的半衰期是109.8分钟。理论上，假设注射 16 小时后测量，放射性可降低至约 1/256。我们第二天早上用伽马探针测量了淋巴结转移巨大的食管鳞癌患者的放射性，但其计数非常细微，因此发现前一天注射的这种方案在临床上不适用。最重要的是，建议在手术前注射^ 18 F-FDG以维持正电子探针的诊断质量和准确性。结论：仍然存在许多有待解决的问题，然而，FDG引导的手术可能是有希望的新方法，有可能成为手术质量的突破。

项目成果

Significance and clinical application of PET in a surgery domain-2

PET在外科领域的意义和临床应用2

• 期刊: Cancer of the esophagus. Surgery (In Press)
• 作者: Yasuda T.;et al.
• 通讯作者: et al.

Utility of FDG-PET in a preoperative curative effect judgment of progress cancer of the esophagus

FDG-PET在食管癌进展期术前疗效判断中的应用

• 发表时间: 2004
• 期刊: Digital Medicine 5(3)
• 作者: Yasuda T.;et al.
• 通讯作者: et al.

進行食道癌の術前治療効果判定におけるFDG-PETの有用性. Digital Medicine

FDG-PET 在确定晚期食管癌术前治疗效果方面的作用

• 发表时间: 2004
• 期刊: Digital Medicine 5.3
• 作者: Okawa T;Naomoto Y;Nobuhisa T;Takaoka M;Motoki T;Shirakawa Y;Yamatsuji T;Inoue H;Ouchida M;Gunduz M;Nakajima M;Tanaka N.;永野浩昭 他;安田卓司 他
• 通讯作者: 安田卓司 他

外科領域におけるPETの意義と臨床応用〜2

PET在外科领域的意义及临床应用~2

• 发表时间: 2006
• 期刊: 食道癌. 外科 68.6(In Press)
• 作者: Nobuhisa T;et al.;安田卓司 他
• 通讯作者: 安田卓司 他

進行食道癌の術前治療効果判定におけるFDG-PETの有用性

FDG-PET 在确定晚期食管癌术前治疗效果中的作用

• 发表时间: 2004
• 期刊: Digital Medicine 5(3)
• 作者: Naomoto Y;Takaoka M;Okawa T;Nobuhisa T;Gunduz M;Tanaka N.;安田卓司 他
• 通讯作者: 安田卓司 他