Regulated adhesion and neo-vascularization with mesothelium in the prefabricated flap

目前，在组织重建领域已经发展了“预制皮瓣”。在这种方法中，血管组织作为“血管载体”在皮瓣抬高之前被植入。几个月后，新制作的皮瓣可以通过血管载体的血液供应而提升。这种方法是基于诱导的血管载体和覆盖组织之间的新生血管。然而，血管载体的新生血管和与周围组织的粘连可能固有地导致皮瓣抬高困难。我们研制了一种以空肠浆肌瓣为血管载体的预制皮瓣。空肠浆肌瓣既有黏膜下层，又有防止粘连和新生血管的浆膜。我们证实了以空肠浆肌瓣为基础的预制皮瓣作为血管载体的应用。

Currently, the "prefabricated flap" has been developed in the field of tissue reconstruction. In this method, a vascularized tissue is implanted as a "vascular carrier" prior to the flap elevation. A few months later, a newly created flap can be elevated with the blood supply via the vascular carrier. This method is based on the neo-vascularization between the induced vascular carrier and the overlying tissue. However, neovascularization and adhesion of the vascular carrier to the surrounding tissue may inherently result in difficulty of the flap elevation. We developed a prefabricated flap using jejunal seromuscular flap as a vascular carrier. The jejunal seromuscular flap contains a submucosal layer for the neovascularization, but also having a serosa which can prevent adhesion and neovascularization. We confirmed the utility of the prefabricated flap based on the jejunal seromuscular flap as a vascular carrier.