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Regulated adhesion and neo-vascularization with mesothelium in the prefabricated flap

预制皮瓣中间皮的调节粘附和新血管形成

基本信息

批准号：
16591802
负责人：
SAKURAI Hiroyuki
金额：
$ 1.79万
依托单位：
Tokyo Women's Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591802/
关键词：
prefabricated flap vascular carrier jejunum serosa rat neovascularization

项目摘要

Currently, the "prefabricated flap" has been developed in the field of tissue reconstruction. In this method, a vascularized tissue is implanted as a "vascular carrier" prior to the flap elevation. A few months later, a newly created flap can be elevated with the blood supply via the vascular carrier. This method is based on the neo-vascularization between the induced vascular carrier and the overlying tissue. However, neovascularization and adhesion of the vascular carrier to the surrounding tissue may inherently result in difficulty of the flap elevation. We developed a prefabricated flap using jejunal seromuscular flap as a vascular carrier. The jejunal seromuscular flap contains a submucosal layer for the neovascularization, but also having a serosa which can prevent adhesion and neovascularization. We confirmed the utility of the prefabricated flap based on the jejunal seromuscular flap as a vascular carrier.

目前，“预制皮瓣”在组织重建领域得到了较好的发展。在这种方法中，在皮瓣提升之前，将带血管的组织作为“血管载体”植入。几个月后，新造的皮瓣可以通过血管载体随着血液供应而升高。该方法是基于诱导血管载体与上覆组织之间的新生血管形成。然而，新生血管和血管载体与周围组织的粘连可能固有地导致皮瓣提升的困难。我们开发了一种以空肠血清肌瓣为血管载体的预制皮瓣。空肠血清肌瓣含有用于新生血管形成的粘膜下层，但也有防止粘连和新生血管形成的浆膜。我们证实了以空肠血清肌瓣为基础的预制皮瓣作为血管载体的实用性。