Effects of relax dental clinic with healing music on the central nervous system, autonomic nervous system, and cardiovascular system

自2002年以来，我们一直在我院放松牙科诊所为牙科恐惧症患者进行牙科治疗。本研究的目的是探讨精神镇静与疗愈性音乐和吸入氧化亚氮对中枢神经系统、自主神经系统和心血管系统的影响。20名健康的年轻成人志愿者参加了这项研究。采用APG heart Rater SA-3000P、Portapres Model 2和BIS监测仪，在吸入30%氧化亚氮并聆听莫扎特、巴赫和维瓦尔第作曲的治疗音乐时，测量TP （Total Power）、平均HRT、LF、HF、归一化LF、归一化HF、LF/HF比、血压、心率、搏量、心输出量、总外周阻力和BIS （bisp）。TP在对照组有升高的趋势，而实验组有降低的趋势，表明自主神经活动受到抑制。虽然对照组的平均HRT没有变化，但实验组的平均HRT从68.0±10.5 bpm明显下降到64.1±8.9 bpm。实验组归一化HF升高。与此相反，在一氧化二氮吸入镇静和听治疗音乐时，正常LF和LF/HF比值降低。收缩压、舒张压和平均血压无明显变化。然而，心率从68.0±10.5 bpm明显下降到64.1±8.9 bpm，并且在实验组中发现BIS值略有下降。TP > 1000ms^2组和TP > 2000ms^2组也表现出类似的趋势。这些结果表明，精神镇静与听疗愈音乐相结合可抑制交感神经活动，加速副交感神经活动。

We have performed dental treatment in patients with dental phobia in the relaxation dental clinic of our hospital since 2002. The purpose of the present study was to investigate the effects of psychosedation with the healing music and nitrous oxide inhalation on the central nervous system, the autonomic nervous system, and the cardiovascular system.Twenty healthy young adult volunteers participated in the study. TP (Total Power), Mean HRT, LF, HF, normalized LF, normalized HF, LF/HF ratio, blood pressure, heart rate, stroke volume, cardiac output, total peripheral resistance and BIS (Bispectral Index) were measured by means of APG Heart Rater SA-3000P, Portapres Model 2, and BIS monitor during 30% nitrous oxide inhalation and listening to the healing music composed by Mozart, Bach, and Vivaldi.TP tended to increase in the control group, but it was apt to decrease in the experiment group, which indicated the depression of the autonomic nervous activities. Although Mean HRT did not change in the control group, it decreased significantly from 68.0±10.5 bpm to 64.1±8.9 bpm in the experiment group. An increase of normalized HF was observed in the experiment group. In contrast with this, normalized LF and LF/HF ratio were reduced during nitrous oxide inhalation sedation and listening to the healing music. No significant changes in systolic diastolic and mean blood pressure were recorded. However, heart rate decreased significantly from 68.0±10.5 bpm to 64.1±8.9 bpm and slight reduction of BIS values were recognizedin the experimental group. The similar tendency was shown in the group of TP more than 1000ms^2 and the group of TP more than 2000ms^2.These results suggested the combination of psychosedation and listening to the healing music brought about the depression of sympathetic nerve activities and the acceleration of parasympathetic nerve activities.