Synthesis of Mono-Functional Olefin Metathesis Polymers

本研究的目的是提供新的合成路线，制备明确的单端功能的复分解聚合物。目前，开环易位聚合（ROMP）允许从大量官能单体合成明确定义的聚合物。然而，准确地引入一个明确定义的功能性端基是难以实现的。虽然即使对于非专业人士来说，这也是一种非常有吸引力的聚合技术，但这一缺点限制了其跨学科边界的应用。我们最近展示了一种新的合成方法，以克服这一限制，使用一个易于遵循的牺牲嵌段共聚物技术。初步工作仅限于羟基官能团。在这里，我们提出了这种方法的发展，以便能够引入各种官能团，如胺，硫醇或羧酸的定义明确的功能聚合物的末端。沿聚合物链沿着携带一种类型的官能团同时在链端提供不同官能度的聚合物难以制备，并且特别可用于合成生物大分子缀合物、嵌段共聚物、表面活性剂、胶体以及表面和纳米颗粒的官能化。

The aim of this research proposal is to provide new synthetic routes for the preparation of well-defined mono-end-functional metathesis polymers. Currently, the ring opening metathesis polymerisation (ROMP) allows the synthesis of well-defined polymers from a large pool of functional monomers. The introduction of exactly one well-defined functional end-group, however, is difficult to achieve. While otherwise a very attractive polymerisation technique even for the non-specialist, this drawback has limited its application across interdisciplinary borders. We recently demonstrated a new synthetic approach to overcome this limitation using an easy to follow sacrificial block-copolymer technique. The preliminary work was limited to hydroxy functional groups. Here we propose the development of this approach in order to be able to introduce a variety of functional groups such as amines, thiols or carboxylic acids to the end of a well-define functional polymer. Polymers carrying one type of functional group along the polymer chain while providing a different functionality at the chain end are otherwise difficult to prepare and particularly useful for the synthesis of biomacromolecule conjugates, block copolymers, surfactants, colloids and the functionalisation of surfaces and nano-particles.