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Lethal effects of exposure to environmental cigarette smoke on Drosophila larvae and its oxidative damage transmitted to the next generation

暴露于环境香烟烟雾对果蝇幼虫的致命影响及其传递给下一代的氧化损伤

基本信息

批准号：
17510044
负责人：
NEGISHI Tomoe
金额：
$ 2.3万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

Epidemiological evidence indicates that cigarette smoke is harmful for our health. Many investigations have documented damage induced by mainstream cigarette smoke. We examined the biological effects induced by environmental cigarette smoke (ECS) using Drosophila. When 3rd instar larvae were exposed to ECS, the eclosion-rate of a urate-null mutant strain decreased significantly compared to that of a wild strain. As urate is considered to function as an antioxidant in Drosophila, cigarette smoke appears to induce oxidative damage in larvae. To estimate the effect of ECS on offspring development, we observed the viability of flies emerging from eggs that were produced by matings between males and females eclosed from larvae exposed or not exposed to ECS. Pairs of the urate-null strain in which both males and females were exposed showed the lowest viability. These results suggest that third instar larvae were damaged by ECS affecting not only their own viability but also that of the next generation.

流行病学证据表明香烟烟雾对我们的健康有害。许多调查都记录了主流香烟烟雾引起的损害。我们研究了环境香烟烟雾（ECS）诱导的果蝇的生物学效应。当3龄幼虫暴露于ECS时，尿酸盐缺失突变株的羽化率与野生株相比显著降低。由于尿酸盐被认为是果蝇体内的抗氧化剂，香烟烟雾似乎会诱导幼虫的氧化损伤。为了估计ECS对后代发育的影响，我们观察了从暴露于或不暴露于ECS的幼虫羽化的雄性和雌性之间的交配产生的卵中出现的苍蝇的生存能力。暴露于雄性和雌性的尿酸盐无效菌株对显示出最低的活力。这些结果表明，三龄幼虫受到损害的ECS不仅影响自己的生活力，但也影响下一代。

项目成果

期刊论文数量（28）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluation of oxidative damage induced by natural sunlight in Drosophila

自然阳光诱导果蝇氧化损伤的评价

DOI：
发表时间：
2006
期刊：
Genes ＆ Environment 28
影响因子：
0
作者：
Kawai;K.;Svoboda;P.;Kasai;Arakawa R.
通讯作者：
Arakawa R.

Involvement of the drug efflux protein TolC in mutagenicity induced by MNNG or Trp-P-2.

药物外排蛋白 TolC 参与 MNNG 或 Trp-P-2 诱导的致突变性。

DOI：
发表时间：
2006
期刊：
Mutattion Research (in press)
影响因子：
0
作者：
Kawai;K.;Svoboda;P.;Kasai;Arakawa R.;Negishi K.;Takahashi E.;Arimoto-Kobayashi S.;Svoboda P.;Kasai H.;Kawai K.;Maekawa M.;Eizo Takahashi
通讯作者：
Eizo Takahashi

Evaluation of oxidative damage induced by natural sunlight in Drosphila

自然阳光诱导果蝇氧化损伤的评价

DOI：
发表时间：
2006
期刊：
Genes & Environment 28
影响因子：
0
作者：
Arakawa;R.;et. al.
通讯作者：
et. al.

Identification of 4-oxo-2-hexenal and other direct mutagens formed in model lipid peroxidation reactions as dGuo adducts.

鉴定在模型脂质过氧化反应中形成的 4-oxo-2-己烯醛和其他直接诱变剂为 dGuo 加合物。

DOI：
发表时间：
2006
期刊：
Chem.Res.Toxicol. 19
影响因子：
0
作者：
Kawai;K.;Svoboda;P.;Kasai;Arakawa R.;Negishi K.;Takahashi E.;Arimoto-Kobayashi S.;Svoboda P.;Kasai H.;Kawai K.;Maekawa M.;Eizo Takahashi;Hidetomo Kobayashi;Sakae Arimoto-Kobayashi;Kazuaki Kawai;Muneyuki Maekawa
通讯作者：
Muneyuki Maekawa

Detection of genotoxic nucleosides, 8-hydroxydeoxyguanosine, 8-hydroxyguanosine and fre base 8-hydroxyguanine, in fish food froducts.

鱼食品中基因毒性核苷、8-羟基脱氧鸟苷、8-羟基鸟苷和游离基 8-羟基鸟嘌呤的检测。