Development of chemiluminescent probes for the bioscience

生物科学化学发光探针的开发

• 批准号: 17510176
• 负责人: TERANISHI Katsunori
• 金额: $ 2.3万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17510176/
• 关键词: Luminescence; 分析

A super oxide is one of active oxygens and is concerned with the immune response and the tissue damage which can be put in the living body, and its abundance is kept by "generation and resolution" appropriately in a healthy living body. Analyses of a super oxide of a living body are one of means to know the immunity power and a tissue damage, and via reacting an analyzed chemiluminescence method changes a super oxide th light signal, and is one of the sensitive assays. the luminous compound which issues blue light or a green light (luminous probe) is used by the present chemical emission spectrometry. The quantity of light which reaches light-sensitive cell for light absorption by a pigment falls remarkably, and these luminescent colors are obstruction of measurement. Development of a luminous compound luminous wavelength possesses in the long wavelength region which can excel optical transparency was tried by this research.Chemical bonding react to a super oxide and stick the elements … More who generate the energy into the fluorescent molecule which issues red fluorescence, the organization which flashes from red fluorescent molecule using an energy transfer was used. When chemical synthesis did this luminous molecule, and a luminous Noh play was estimated using the super oxide occurrence system, emission intensity reacted to a super oxide and didn't cause emission of light from the elements who generate the energy, and confirmed the emission of light only of red light, and moreover confirmed the high thing more than the former luminous compound. Since putting it in this emission of light, it was proved that an energy transfer has formed efficiently. A luminous compound which reacts to a super oxide and is different from the elements who generate the energy in the combination style with the red fluorescent molecule, after several kinds of emission intensity of chemical synthesis perilla was estimated, it was revealed that this combination style influencesemission intensity remarkably. Less

超氧化物是活性氧之一，与免疫反应和组织损伤有关，可以放入活体，其丰度通过在健康的活体中适当地“生成和分解”来保持。分析活体的超氧化物是了解免疫力和组织损伤的手段之一，并且通过反应分析的化学发光方法改变超氧化物的光信号，并且是灵敏的测定之一。本化学发射光谱法使用发出蓝光或绿色光的发光化合物（发光探针）。到达光敏细胞以被色素福尔斯吸收光的光量显著下降，并且这些发光颜色成为测量的障碍。本研究尝试开发一种发光波长在长波长范围内，且透光性较好的发光化合物，其化学键合反应是通过超氧化物将元素粘结在一起 ...更多信息 其将能量产生到发出红色荧光的荧光分子中，使用利用能量转移从红色荧光分子闪烁的组织。当化学合成这种发光分子时，使用超氧化物发生系统来估计发光的Noh发挥，发射强度与超氧化物反应，并且不引起来自产生能量的元素的光的发射，并且确认了仅红光的光的发射，并且还确认了比以前的发光化合物更高的东西。自从把它放在这个发光，它被证明是一个能量转移已经有效地形成。一种与超氧化物反应的发光化合物，与红色荧光分子以结合方式产生能量的元素不同，通过对化学合成紫苏的几种发光强度的估算，揭示了这种结合方式对发光强度的影响显著。少

项目成果

Luminescence of Imidazo[1,2-α]pyrazin-3(7H)-one Compounds

咪唑并[1,2-α]吡嗪-3(7H)-酮化合物的发光

• 发表时间: 2007
• 期刊: Bioorganic Chemistry 35
• 作者: Shibata J;Ren F;Nishizawa M;Fujno M;Iwatani Y;Matsuda M;Miura H;Tanaka H;Sugiura W.;K.Teranishi;K.Teranishi
• 通讯作者: K.Teranishi

イミダゾキノキザリノン化学発光物質、その製造法、および発光分析法

咪唑喹喔啉酮化学发光物质、其制造方法以及发光分析方法

• 发表时间: 2006

シクロデキストリン誘導体の単離精製方法

环糊精衍生物的分离纯化方法

• 发表时间: 2005

バイオ・ケミルミネセンスハンドブック

生物化学发光手册

• 发表时间: 2006
• 作者: Tanaka T.;et al.;中島芳浩;中島芳浩;中島芳浩;中島芳浩
• 通讯作者: 中島芳浩

化学発光物質

化学发光物质

• 发表时间: 2005