Noninvasive determination and restoration of language localization using the cerebral oscillatory changes

b[1]无创语言定位识别方法的建立及其与有创方法的比较1)合成孔径磁强计无创语言定位测定我们在无声阅读任务的基础上应用了自主语音任务。研究了不同任务对振荡变化的影响。假名阅读与汉字阅读的比较表明，汉字阅读在颞枕基础上表现出更强的非同步性。比假名阅读（平田，日雄，2006）。考察了词语的情感内涵。情绪性词语在前额叶皮层和扣带皮层的失同步现象更为突出。前额叶失同步的侧化表现为消极情绪词与积极情绪词之间的逆转。此外，情绪性词语表明额叶下皮层的去同步性增加（Hirata, neuromage, 2007）。2)清醒手术时慢性硬膜下电极和术中皮质刺激的比较验证研究表明，合成孔径磁强计和当前的默读任务可以很好地检测语言定位（Hirata， Biomag 2006和ICCN 2006）语言活动诱发局部脑振荡变化的时空分析引入脑磁图组分析，建立默读任务（准备中）诱发局部脑振荡变化的正常标准[b]经颅磁刺激语言功能评估经医院伦理委员会批准后进行评估b[4]脑机接口语言功能恢复正在调查分类词的时空分布。采用支持向量机判别分析评估语言功能恢复的可行性

[1] Establishment of noninvasive identification of language localization and comparison with invasive methods1) Noninvasive determination of language localization using synthetic aperture magnetometryWe applied a voluntary speech task in addition to a silent reading task. Difference of oscillatory changes by different tasks were investigated. Comparison between kana reading and kanji reading indicated that kanji reading showed stronger desynchronization in the temporooccipital base.than kana reading (Hirata, Risho Noha, 2006). Emotional connotation in words was investigated. Emotional words indicated more prominent desynchronization in the prefrontal cortex and cingulate cortex. Lateralization of the prefrontal desynchronization was reversal between negative and positive emotional words. In addition, Emotional words indicated increased desynchronization in the inferior frontal cortex (Hirata, Neurolmage, 2007).2) Comparison with chronic subdural electrodes and intraoperative cortical stimulation during awake surgeryValidation study indicated that language localization was well detectable with synthetic aperture magnetometry and the present silent reading task (Hirata, Biomag 2006 and ICCN 2006).[2] Spatiotemporal analyses of local cerebral oscillatory changes induced by language activitiesGroup analyses of MEG was introduced to establish the normal standard of oscillatory changes induced by silent reading task ( in preparation).[3] Evaluation of language function using transcranial magnetic stimulationEvaluation will be performed after the approval by the hospital ethical committee[4] Restoration of language function using brain computer interfaceSpatiotemporal distribution of the categorized words is being investigated. Feasibility of the restoration of language function was assessed by discrimination analyses using support vector machine