Elucidation of apperception mechanism in CIPA-analysis by both animal models and magnetoencephalogram

对于CIPA的统觉机制的阐明，主要从脑磁图上进行研究。（1）为了阐明CIPA的统觉机制，我们主要研究了脑磁图。我们用体感诱发脑磁图（SEF）评估CIPA患者。结果：电刺激对侧前臂区皮肤，记录到20、40、70msec的峰潜伏期。在对侧初级躯体感觉区（SI）观察由SEF推测的潜伏期为20ms的等效电流偶极子（ECD）。这些结果与正常人的数据几乎一致。所有受试者对侧初级躯体感觉区（SI）均出现另一潜伏期的ECDs，与正常人的结果基本一致。这些结果表明，CIPA的统觉机制，特别是通过A6纤维的统觉机制与正常人的数据相似。(2)We对CIPA患者进行了Neurometer和QST两种方法的试验，目的是建立CIPA患者无创性周围神经纤维选择性刺激方法。因此，QST可用于CIPA患者的周围神经可用性测试，但应谨慎使用Neurometer，特别是在评估有髓纤维的情况下。(3)As CIPA患者的动物模型，我们尝试建立各种动物模型。在此过程中，我们发现广泛应用于动物实验性疼痛模型的福尔马林实验，在所用的浓度范围内，对不同的神经纤维都有刺激作用，以上就是我们所得到的全部成果。

For apperception mechanism elucidation in CIPA weudied it mainly on magnetoencephalogram.(1)For elucidation of apperception mechanism in CIPA, we mainly studied on magnetoencephalogram. We evaluated CIPA patients by somatosensory elicitation magnetoencephalo ground(SEF). As a result, 20, 40, 70 msec peak latency were recorded in a contra side by anterior brachial region skin electric stimulation. We observed Equivalent Current Dipoles(ECDs) which was supposed from SEF in latency 20ms in contra side primary somatosensor area(SI) of all subjects. These results almost accorded with data of normal subjects. ECDs in another latency was found in contra side primary somatosensor area(SI) of all subjects, these results almost accorded with data of normal subjects. These results suggested that apperception mechanism in CIPA, especially through A 6 fibers, is similar to the data of normal subjects.(2)We tried both Neurometer and QST to the CIPA patients for the purpose of establishing noninvasive peripheral nerve fibrous elective irritation methods to the CIPA patients. As a result, QST was useful for a peripheral nerve usability test for the CIPA patients, however, Neurometer should be used with careful attention, especially in case of evaluating myelinated fibers.(3)As animal models of the CIPA patient, we tried to establish various animal models. In the process, we found that a formalin test which widely used as an animal experimental pain model could stimulated different nerve fiber by the used concentration.The above is all fruit we got.