Effectors of MAP kinase signaling during plant embryogenesis

植物胚胎发生过程中 MAP 激酶信号传导的效应器

• 批准号: 494821461
• 负责人: Dr. Martin Bayer
• 金额: --
• 依托单位: Zentrum für Molekularbiologie der Pflanzen (ZMBP)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/494821461?language=en
• 关键词: Effectors; MAP; kinase; signaling; during

Multicellular organisms develop their complex body shape from genetically identical cells. To achieve this, cells initiate different transcriptional responses in daughter cells of asymmetric cell divisions. We use the early Arabidopsis embryo as model system to get molecular, mechanistic insight into the signaling events that orchestrate cellular differentiation in plant stem cell systems.In recent years, it has become clear that the ERECTA-YODA MAP kinase signaling pathway plays a central role in cell polarization and differential gene expression in asymmetric cell divisions in plants.In the early Arabidopsis embryo, however, little is known about the molecular targets of MAP kinase phosphorylation and how different cell identities and auxin responses are achieved in the daughter cells on a molecular level.In the proposed project, we will functionally characterize transcription factors and transcriptional repressors as targets of the embryonic ERECTA-YODA pathway. With this project, we will get mechanistic insight in stem cell homeostasis and how different cell identities are achieved during plant development.

多细胞生物从遗传上相同的细胞发育出复杂的身体形状。为了实现这一点，细胞在不对称细胞分裂的子细胞中启动不同的转录反应。我们以拟南芥早期胚胎为模型系统，从分子和机制上深入了解植物干细胞系统中调控细胞分化的信号事件。近年来，ERECTA-Yoda MAP激酶信号通路在植物细胞不对称分裂中的细胞极化和差异基因表达中起着核心作用。然而，在拟南芥早期胚胎中，对于MAP激酶磷酸化的分子靶点以及在子代细胞中如何在分子水平上实现不同的细胞身份和生长素反应，我们知之甚少。在拟议的项目中，我们将从功能上表征转录因子和转录抑制因子作为胚胎ERECTA-Yoda途径的靶标。通过这个项目，我们将从机制上深入了解干细胞的动态平衡，以及在植物发育过程中不同的细胞身份是如何实现的。