Improving and manipulating the immune adjuvant properties of recombinant fowlpox vectors

改进和操纵重组鸡痘载体的免疫佐剂特性

• 批准号: LP0561810
• 负责人: Prof John Hayball
• 金额: $ 11.57万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-12-21 至 2008-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0561810
• 关键词: Improving; manipulating; immune; adjuvant; properties

Unbalanced immune responses may cause or worsen common and important diseases such as infections, allergies, cancers and autoimmunity. Interleukin-4 (IL-4) is the only immune active product or cytokine that safely skews an aberrant immune response to a healing type of response. Fowlpox viruses (FPV) provide safe and effective human vaccines. Engineering FPV to make both a relevant antigen and a cytokine is proprietary technology. With our commercial partner and using experimental mice, we will test the concept that FPV making a model antigen and IL-4 initiate and/or maintain beneficial Type 2 responses. A successful outcome will guide clinical FPV-based vaccine development for the treatment of important human and veterinary diseases.

不平衡的免疫反应可能导致或恶化常见和重要的疾病，如感染，过敏，癌症和自身免疫。白细胞介素-4（IL-4）是唯一的免疫活性产物或细胞因子，其安全地使异常免疫应答偏向于愈合型应答。鸡痘病毒（FPV）是一种安全有效的人类疫苗。工程FPV，使相关抗原和细胞因子是专有技术。与我们的商业合作伙伴和使用实验小鼠，我们将测试FPV产生模型抗原和IL-4启动和/或维持有益的2型应答的概念。成功的结果将指导临床FPV疫苗的开发，用于治疗重要的人类和兽医疾病。