Epigenetic clocks, blood-based biomarkers and functional parameters for the estimation of biological age (C06)

目前还没有找到一个合适的生物年龄模型。在这个项目中，我们使用已经很好表征的ActiFE队列来开发一个基于血液生物标志物、相关临床和功能参数以及靶向表观遗传时钟的生物年龄模型。该分析还将整合基于DNA甲基化分析的新概念。在翻译方法中，我们也将检查小鼠的表观遗传时钟。我们的联合研究将探讨生物年龄、脆弱和表观遗传衰老之间的联系，为生物年龄评估提供新的构建。

There is an unmet need to find an adequate model for biological age. In this project, we use the well characterized ActiFE cohort to develop a model for biological age based on blood-based biomarkers, relevant clinical and functional parameters, and targeted epigenetic clocks. The analysis will also integrate new concepts based on DNA methylation analysis. In a translational approach we will examine epigenetic clocks also in mice. Our joint research will investigate the interface between biological age, frailty, and epigenetic aging to provide a new construct for biological age assessment.