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脳の可塑性と神経伝達・調節物質代謝及び脳活動基調の時空特性

大脑可塑性、神经传递、调节物质代谢以及大脑活动趋势的时空特征

基本信息

批准号：
08270211
负责人：
高井克治
金额：
$ 1.28万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1996
资助国家：
日本
起止时间：
1996 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-08270211/
关键词：
動的コード

项目摘要

当研究チームは、ラット脳の微小領域単位で、広域調節系神経伝達物質[ドーパミン(DA)・ノルエピネフリン(NE)・セロトニン(5-HT)]の定常水準・遊離の連続時間追跡・誘発を行った結果、全脳や局所の限定追及では求め得ない明確な領域・時間特性が観測され、時空的、系間比較した結果、此等の“前シナプス過程"には、複数の時間特性を持つ内在性の“動的コード(Dynamic Codings)"の階層が存在し、特に5-HT/NE定常水準の反極性24h周期の遷移と此のCodingの脳幹・視床・視床株・海馬、皮質等の領域間の順位相・他領域での逆相同調を典型とする“系・領域間関連"、又、上行性調節系稠密投射を受ける皮質・辺縁系調節系起始領域で、脳基調調節領域である中隔縦束(MSDB)や前脳基底部に於いては、3つのアミン系定常水準共優勢と著明なDA/NE定常水準の逆極性短周期(2-3h)同調、及び、誘発応答特性に基づくDA/NEの非小胞体遊離機構優位の示唆、等が示された。此等の内在代謝Codingsの幾つかは、覚醒・睡眠や行動など生理的脳基調の相交替の内在時間特性に密接に関連し、5-HTの血中前駆体Trp酵素的(TSO)分解による迅速可逆的全脳5-HT除去擾乱に際しては、5-HT/NE水準遷移は解消する一方、意識の水準(覚醒・睡眠)と行動相の24時間周期交替は分単位短周期に崩壊した。此の際、微小領域のMultiunit Activity追跡から、生物時計候補視覚交差上核明期優勢日周律動は完全維持、これに反極の皮質、視床活動の消失も著明でなく、MSDBなどの少数領域に、活動の日周律動消失・短周期化が観測されている。此の事実は、5-HT系擾乱が、偏在する時計機構と脳基調の結合の擾乱、又は、特定局所でのSCN時間伝達・発現機構の遮断、の可能性を示唆するものである。

When studying the steady state level, ionization time trace, induction results, total domain restriction results, clear domain, time characteristic measurement, spatiotemporal, intersystem comparison results, and these "pre-process" of the micro-domain, domain regulation system of the substance [D (DA)·N (NE)·N (5-HT)], The time characteristic of plural numbers keeps the intrinsic property of "moving"(Dynamic Codings)"Hierarchy" exists, especially 5-HT/NE steady level reverse polarity 24h cycle migration, this coding stem, optic bed, optic bed strain, hippocampus, cortex, etc."system, domain correlation", and "ascending regulatory system dense projection", cortex, hippocampus, cortex, etc." The key regulation domain is composed of two parts: the first part is composed of the base part, the second part is composed of the base part, the third part is composed of the base part, the third part is composed of the base part, the fourth part is composed of the base part, the base part, the fourth part is composed of the base part, the base part, the fourth part is composed of the base part, the fourth part is composed of the base part, the base part, These intrinsic metabolic Codings are closely related to the intrinsic temporal characteristics of the physiological phase alternation between waking and sleep activity, the rapid and reversible decomposition of 5-HT by the blood precursor Trp enzyme (TSO), and the complete 5-HT removal of disturbances in the phase alternation between waking and sleep activity, the level of consciousness (waking and sleep), and the 24-time cycle of the action phase alternation. At this time, the Multiunit Activity tracking of micro-field is not completed, the dominant diurnal rhythm of the nucleus is completely maintained on the cross difference of the biochronometer candidate, the activity of the cortex and optic bed of the opposite pole is disappeared, the activity of the MSDB is disappeared, and the diurnal rhythm of the activity is disappeared. This is because 5-HT is disturbing the timing mechanism, the combination of the timing mechanism and the timing mechanism, and the possibility of the SCN timing mechanism in a specific location.