Signaling of intrinsic angiogenesis inhibition in cancer tissues

研究了内皮细胞（EC）合成的血管生成负反馈调节因子血管抑制素-1（VASH-1）和拮抗VASH-1的血管抑制素-2（VASH-2）的作用。病理学分析显示VASH-1表达于肿瘤血管内皮细胞中，其表达与肿瘤细胞中VEGF的表达、病理分级及肿瘤细胞增殖率相关。动物模型显示，内源性VASH-1调节肿瘤血管生成，但外源性补充VASH-1进一步表现出抗血管生成和抗淋巴管生成活性，并抑制肿瘤生长和淋巴结转移。VASH-2在癌间质中浸润的单核细胞以及癌细胞中显示，并且VASH-2通过刺激血管生成促进肿瘤生长。

The role of vasohibin-1(VASH-1), a negative feedback regulator of angiogenesis synthesized by endothelial cells(ECs), and vasohibin-2(VASH-2) which antagonizes VASH-1 was studied. Pathological analysis revealed that VASH-1 was present in ECs in tumor vessels, which was correlated with VEGF in cancer cells, pathological grading, and proliferation rate of cancer cells. Animal models revealed that endogenous VASH-1 regulates tumor angiogenesis, but exogenous supplementation of VASH-1 further exhibited anti-angiogenic and anti-lymphangiogenic activities and inhibited tumor growth and lymph node metastasis. VASH-2 was shown in mononuclear cells infiltrating in cancer stroma as well as in cancer cells, and VASH-2 promoted tumor growth by stimulating angiogenesis.