Signaling of intrinsic angiogenesis inhibition in cancer tissues

癌症组织中内在血管生成抑制的信号传导

• 批准号: 17014006
• 负责人: SATO Yasufumi
• 金额: $ 36.42万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17014006/
• 关键词: 腫瘍血管新生; 内因性調節因子; vasohibin-1; vasohibin-2; Vasobihin-1; ELISA; Vasohibin-1 KOマウス; Vasohibin-2; Vasohibin-1; 乳癌; SVBP; Glu-チューブリン; チューブリンチロシンリガーゼ; 微小管; 細胞遊走; 子宮体癌; 非小細胞肺癌; バイオマーカー; 標的遺伝子; VEGF 1 型受容体; 血管内皮細胞; 壁細胞; 成熟血管; リンパ管新生; 血管新生

The role of vasohibin-1(VASH-1), a negative feedback regulator of angiogenesis synthesized by endothelial cells(ECs), and vasohibin-2(VASH-2) which antagonizes VASH-1 was studied. Pathological analysis revealed that VASH-1 was present in ECs in tumor vessels, which was correlated with VEGF in cancer cells, pathological grading, and proliferation rate of cancer cells. Animal models revealed that endogenous VASH-1 regulates tumor angiogenesis, but exogenous supplementation of VASH-1 further exhibited anti-angiogenic and anti-lymphangiogenic activities and inhibited tumor growth and lymph node metastasis. VASH-2 was shown in mononuclear cells infiltrating in cancer stroma as well as in cancer cells, and VASH-2 promoted tumor growth by stimulating angiogenesis.

血管肽-1（VASH-1）的作用是由内皮细胞（ECS）合成的负反馈调节剂（ECS）和血管肽-2（VASH-2）的负反馈调节剂，研究了对VASH-1的拮抗。病理分析表明，肿瘤血管中的EC中存在VASH-1，肿瘤血管中与癌细胞中的VEGF相关，病理分级和癌细胞的增殖率相关。动物模型表明，内源性VASH-1调节肿瘤血管生成，但是对Vash-1的外源补充进一步表现出抗血管生成和抗淋巴染活性，并抑制肿瘤的生长和淋巴结转移。 VASH-2在癌基质和癌细胞中浸润的单核细胞中显示，Vash-2通过刺激血管生成促进肿瘤生长。

项目成果

リンパ管新生の内因性抑制因子に関する研究

淋巴管生成内源性抑制因子的研究

• 发表时间: 2007
• 作者: Kanemura H.;Iimuro Y.;Fujimoto J.;et.al.;佐藤靖史
• 通讯作者: 佐藤靖史

血管新生制御におけるvasohibin familyの役割

血管抑制素家族在调节血管生成中的作用

• 发表时间: 2007
• 作者: Yano;Y;Truong;BX;Seo;Y;Kato;H;Mild;A;Tanaka;Y;Mizokami;M;Kagawa;A;Miyazaki;H;Kasuga;M;Azuma;T;Hayashi;Y;佐藤靖史
• 通讯作者: 佐藤靖史

Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is required for the development of vascular as well as hematopoietic system in embryoid bodies

• DOI: 10.1111/j.1365-2443.2006.00978.x
• 发表时间: 2006-07-01
• 期刊: GENES TO CELLS
• 影响因子: 2.1
• 作者: Abe, Mayumi;Sato, Yasufumi
• 通讯作者: Sato, Yasufumi

Inflammatory Cytokine-induced Expression of Vasohibin-1 by Rheumatoid Synovial Fibroblasts

炎症细胞因子诱导类风湿滑膜成纤维细胞表达 Vasohibin-1

• 发表时间: 2009
• 期刊: Acta Medica Okayama 63
• 作者: Miyake K;Nishida K;Kadota Y;Yamasaki H;Nasu T;Saitou D;Tanabe K;Sonoda H;Sato Y;Maeshima Y;Makino H.
• 通讯作者: Makino H.

Vasohibin, a novel endothelium-derived angiogenesis inhibitor : its expression on endometrial carcinoma in relation to tumor vascularity

血管抑制素，一种新型内皮源性血管生成抑制剂：其在子宫内膜癌中的表达与肿瘤血管的关系

• 发表时间: 2008
• 期刊: Cancer Sci 99
• 作者: Yoshinaga;K.;Moriya;T.;Nagase;S.;Takano;T.;Niikura;H.;Ito;K.;Nobuo Yaegashi;N.;and Sato;Y
• 通讯作者: Y