Signaling of intrinsic angiogenesis inhibition in cancer tissues

研究了内皮细胞合成的血管生成负反馈调节因子VASH-1和拮抗VASH-1的VASH-2的作用。病理分析显示，VASH-1表达于肿瘤血管内皮细胞中，其表达与肿瘤细胞中的血管内皮生长因子、肿瘤细胞的病理分级、细胞的增殖率有关。动物模型显示，内源性VASH-1调节肿瘤血管生成，而外源性VASH-1进一步表现出抗血管生成和抗淋巴管生成活性，并抑制肿瘤生长和淋巴结转移。VASH-2在肿瘤间质和癌细胞中均有表达，VASH-2通过刺激血管生成促进肿瘤生长。

The role of vasohibin-1(VASH-1), a negative feedback regulator of angiogenesis synthesized by endothelial cells(ECs), and vasohibin-2(VASH-2) which antagonizes VASH-1 was studied. Pathological analysis revealed that VASH-1 was present in ECs in tumor vessels, which was correlated with VEGF in cancer cells, pathological grading, and proliferation rate of cancer cells. Animal models revealed that endogenous VASH-1 regulates tumor angiogenesis, but exogenous supplementation of VASH-1 further exhibited anti-angiogenic and anti-lymphangiogenic activities and inhibited tumor growth and lymph node metastasis. VASH-2 was shown in mononuclear cells infiltrating in cancer stroma as well as in cancer cells, and VASH-2 promoted tumor growth by stimulating angiogenesis.