Mechanisms for the regulation of growth and cell death in cancer cells

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In order to build fundamentals for developing novel cancer treatment, we have analyzed the functions of VCP (an ATPase), which is involved in cell growth and cell death. Resultantly, we identified VCP being modified at many amino acid residues, by which VCP is involved in the cellular functions such as controls of cell cycle and reactive oxygen species. In most of examined advanced adeno-carcinomas and squamous cell carcinomas, we observed highly elevated expression of VCP and p47, a VCP co-factor, suggesting their involvement in the invasion and metastasis.