Molecular Diagnosis of Breast Cancer Characteristics for Personalized Medicine
Molecular Diagnosis of Breast Cancer Characteristics for Personalized Medicine
批准号:
17015027
负责人:
NOGUCHI Shinzaburo
金额:
$32.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
We have been able to construct diagnostic systems for prognosis of breast cancer patients treated with adjuvant hormonal therapy alone, taking advantage of gene expression analysis and cell cycle profiling analysis. Our systems were found to be superior to the conventional clinicopathological prognostic parameters. In addition, we have been able to construct a diagnostic system for response to neoadjuvant chemotherapy consisteing of taxane followed by anthracycline in breast cancer patients.
期刊论文(93)
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DOI:
10.1111/j.1524-4741.2008.00642.x
发表时间:
2008-11-01
期刊:
BREAST JOURNAL
影响因子:
2.1
作者:
[Akazawa, Kenji, Tamaki, Yasuhiro, Noguchi, Shinzaburo]
通讯作者:
Noguchi, Shinzaburo
DOI:
10.1007/s10549-007-9874-3
发表时间:
2008-12-01
期刊:
BREAST CANCER RESEARCH AND TREATMENT
影响因子:
3.8
作者:
[Nakayama, Satoshi, Miyoshi, Yasuo, Noguchi, Shinzaburo]
通讯作者:
Noguchi, Shinzaburo
Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression. Cancer Sci, 2009.
干细胞标记物醛脱氢酶 1 阳性乳腺癌的特点是雌激素受体阴性、人表皮生长因子受体 2 型阳性以及 Ki67 高表达。
DOI:
--
发表时间:
2009
期刊:
Cancer Sci 100
影响因子:
--
作者:
[Morimoto K., et al.]
通讯作者:
et al.
Ratio of cyclin-dependent kinase 1 (CDK1) activity to CDK2 activity after ex vivo paclitaxel treatment predicts response to paclitaxel in human breast cancer.
离体紫杉醇治疗后细胞周期蛋白依赖性激酶 1 (CDK1) 活性与 CDK2 活性的比率可预测人类乳腺癌对紫杉醇的反应。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Kim, S.J., Ishihara, H., Noguchi, S.]
通讯作者:
S.
乳癌に対するFEC100療法におけるMDM2遺伝子多型(SNP309)と骨髄抑制に関する検討
MDM2基因多态性(SNP309)与FEC100治疗乳腺癌的骨髓抑制研究
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[沖代格次, 他]
通讯作者:
他
共 66 条
Clinical Application of Genetic Diagnosis of Breast Cancer
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批准号:11307019
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项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$25.4万
-
财政年份:1999
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负责人:NOGUCHI Shinzaburo
-
依托单位:
海外基金