Cell surface antigenic molecules as targets for immunotherapy

细胞表面抗原分子作为免疫治疗的靶标

• 批准号: 17016049
• 负责人: HINODA Yuji
• 金额: $ 28.8万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17016049/
• 关键词: がん; 免疫療法; 細胞表面抗原分子; 樹状細胞; mRNA; Wntシグナル経路; frizzled-7; 大腸癌; Frizzled-7; si-RNA; 樹状細胞療法; 細胞プロセシング; rizzled-7; 大腸癌細胞; siRNA; 免疫学的モニタリング; 結核菌抗原; Interferon-γ; 抗体療法; RHAMM; モノクローナル抗体

For the purpose of development of the immunotherapy targeting cell surface antigenic molecules, we evaluated dendritic cell therapy using mRNA as antigen and antibody therapy in this study. For dendritic cell therapy, we performed the preclinical studies with several mouse models and then its clinical application in liver, biliary and pancreatic cancer patients. With regard to antibody therapy, we examined the molecules that express in cancer stem cells and found that a receptor molecule, Frizzled-7, is highly expressed in colorectal cancer and could be a potential therapeutic target.

为了开发针对细胞表面抗原分子的免疫疗法，我们在本研究中评估了使用mRNA作为抗原和抗体疗法的树突状细胞疗法。对于树突状细胞疗法，我们用几种小鼠模型进行了临床前研究，然后将其临床应用于肝癌、胆道癌和胰腺癌患者。在抗体治疗方面，我们检查了癌症干细胞中表达的分子，发现一种受体分子Frizzled-7在结直肠癌中高表达，可能是潜在的治疗靶点。

项目成果

The bcl2-938CC Genotype Has Poor Prognosis and Lower Survival in Renal Cancer

• DOI: 10.1016/j.juro.2009.03.081
• 发表时间: 2009-08-01
• 期刊: JOURNAL OF UROLOGY
• 影响因子: 6.6
• 作者: Hirata, Hiroshi;Hinoda, Yuji;Dahiya, Rajvir
• 通讯作者: Dahiya, Rajvir

Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis

• DOI: 10.1093/carcin/bgi029
• 发表时间: 2005-05-01
• 期刊: CARCINOGENESIS
• 影响因子: 4.7
• 作者: Nosho, K;Yoshida, M;Imai, K
• 通讯作者: Imai, K

Aneuploidy Predicts Outcome in Patients with Endometrial Carcinoma and Is Related to Lack of CDH13 Hypermethylation

• DOI: 10.1158/1078-0432.ccr-07-4609
• 发表时间: 2008-06
• 期刊: Clinical Cancer Research
• 影响因子: 11.5
• 作者: Y. Suehiro;T. Okada;Takae Okada;K. Anno;N. Okayama;Koji Ueno;Mikako Hiura;Mikiko Nakamura;T. K

Vaccine therapy with dendritic cells transfected with II13ra2 mRNA for glioma in mice.

使用转染 II13ra2 mRNA 的树突状细胞进行小鼠神经胶质瘤疫苗治疗。

• 发表时间: 2009
• 期刊: J Neurosurg Epub ahead of print
• 作者: Hirata H;Hinoda Y;Kikuno N;Suehiro Y;Shahryari V;Ahmad AE;Tabatabai ZL;Igawa M;Dahiya R;Okada Toshiyuki;Ueno Koji;Saka Makoto
• 通讯作者: Saka Makoto

MUC1 peptide vaccination in patients with advanced pancreas or biliary tract cancer.

晚期胰腺癌或胆道癌患者的 MUC1 肽疫苗接种。

• 发表时间: 2005
• 期刊: Anticancer Res 25・5
• 作者: Nosho K;Yoshida M;Yamamoto H;Taniguchi H;Adachi Y;Mikami M;Hinoda Y;Imai K;Yamamoto et al.
• 通讯作者: Yamamoto et al.