A search and its mechanism elucidation of a new molecular target for radiosensitization

对构成辐射敏感性的候选基因和分子进行了鉴定，并研究了针对它们的辐射增敏策略。因此，HER家族、Hsp90、H_2AX和COX-2等分子与放射增敏密切相关，并根据宫颈癌患者的治疗方式观察到基因表达特征的变化，因此，它可以成为放射增敏的候选分子。

Identification of the candidate gene and molecule constituting radiosensitivity and investigation of radiosensitization strategies which targeted them were performed. Consequently, it became evident that it can become a candidate moleculefor radiosensitization since molecules, such as HER family, Hsp90, H2AX, and CoX-2, are closely connected with radiosensitivity, and that characteristic changes in gene expression characteristic were observed according to the treatment modalities for cervical cancer patients.