Molecular mechanism of cancer immunosurveillance and its application to cancer therapy

癌症免疫监视的分子机制及其在癌症治疗中的应用

• 批准号: 17016071
• 负责人: YAGITA Hideo
• 金额: $ 47.68万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17016071/
• 关键词: がん; 免疫; 抗体療法; キラーT細胞; ナチュラルキラー細胞; 免疫賦活化; CD27; PD-1; B7-H3; Tim-3; D114; 膵癌; 抗DR5抗体; プロテアソーム阻害剤; ヒストン脱アセチル化酵素阻害剤; 抗ErbB-2抗体; IL-21; CTL; 乳癌; 腎癌; DR5; CD40; CD137; NKT細胞; α-GalCer; PD-L1; plasmacytoid DC; NK細胞; 樹状細胞; TRAIL; CD

By characterizing the molecular mechanism of tumor cell recognition and lysis by cytotoxic T cells and natural killer cells, we have developed the anti-DR5 therapy which mimics it. We have also developed novel strategies to augment anti-tumor immunity by using antibodies activating the immuno-stimulatory pathways (such as CD40, CD27, and 4-1BB) and those blocking the immuno-suppressive pathways (such as CTLA-4, PD-1, and B7-H3).

通过研究细胞毒性T细胞和自然杀伤细胞识别和溶解肿瘤细胞的分子机制，我们开发了模拟其的抗DR 5治疗，并开发了通过使用抗体激活免疫刺激途径来增强抗肿瘤免疫的新策略在一些实施方案中，免疫抑制剂包括阻断免疫抑制途径的那些（如CD 40、CD 27和4-1BB）和阻断免疫抑制途径的那些（如CTLA-4、PD-1和B7-H3）。

项目成果

NKG2A inhibits invariant NKT cell activation in hepatic injury.

• DOI: 10.4049/jimmunol.182.1.250
• 发表时间: 2009-01-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Kawamura T;Takeda K;Kaneda H;Matsumoto H;Hayakawa Y;Raulet DH;Ikarashi Y;Kronenberg M;Yagita H;Kinoshita K;Abo T;Okumura K;Smyth MJ
• 通讯作者: Smyth MJ

Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model

• DOI: 10.3892/ijo_00000387
• 发表时间: 2009-10-01
• 期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
• 影响因子: 5.2
• 作者: Okudaira, Keisuke;Hokari, Ryota;Miura, Soichiro
• 通讯作者: Miura, Soichiro

Sequential activation of NKT cells and NK cells provides effective innate immunotherapy cancer.

NKT 细胞和 NK 细胞的顺序激活提供了有效的先天免疫治疗癌症。

• 发表时间: 2005
• 期刊: J.Exp.Med. 201
• 作者: Kaneda H;Takeda K;Ota T;Kaduka Y;Akiba H;Ikarashi Y;Wakasugi H;Kronenberg M;Kinoshita K;Yagita H;Okumura K;Mitani K;Kaneda H.;Takeda K.;Ota T.;Kaduka Y.;Smyth M.J.
• 通讯作者: Smyth M.J.

Jagged2によるNK細胞活性化制御の解析

Jagged2对NK细胞激活的调控分析

• 发表时间: 2007
• 作者: Kaneda H;Takeda K;Ota T;Kaduka Y;Akiba H;Ikarashi Y;Wakasugi H;Kronenberg M;Kinoshita K;Yagita H;Okumura K;Mitani K;Kaneda H.;Takeda K.;Ota T.;Kaduka Y.;Smyth M.J.;杉浦大輔;中山勝文;野見武男;野見武男;中山勝文;竹田和由;山戸一郎;八木田秀雄;Kijima Mika
• 通讯作者: Kijima Mika

TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage

• DOI: 10.1016/j.bbrc.2005.03.176
• 发表时间: 2005-06-03
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Kaduka, Y;Takeda, K;Okumura, K
• 通讯作者: Okumura, K