Local neuronal circuit in the motor cortical areas

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We developed a tool for the study of the local circuit of the motor cortical areas, and obtained the following results on the local circuit using the "From one to group" strategy:(1)The local output of GABAergic cortical interneurons to corticospinal projection neurons (CSNs) was analysed, and found that each interneuron group differentially innervated CSNs.(2)We developed BAC transgenic mice and rats expressing dendritic membrane targeted GFP under the specific control of parvalbumin (PV) promoter, and examined the excitatory and inhibitory inputs to PV-expressing interneurons.(3) We developed adenoviral vector that enable Golgi-stain-like retrograde labeling of cortical neurons, and studied the local connections of pyramidal neurons to corticothalamic projection neurons.