Neuronal mechanisms of initiation and selection of adaptive locomotor behaviors

适应性运动行为的启动和选择的神经机制

• 批准号: 17075002
• 负责人: TAKAKUSAKI Kaoru
• 金额: $ 108.67万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17075002/
• 关键词: 歩行; 姿勢制御; 情動; 随意運動; ドーパミン; 適応; 自律神経系; 二足歩行; 四足歩行; 大脳皮質運動領域; 大脳皮質; 脳幹

To initiate locomotion, predictive postural control based on cognitive information is essential. During ongoing locomotion, real-time postural control depending on sensory signals from mechanoreceptors is also required. In the present study, attempts have been made to examine integrate mechanisms of posture and locomotion in the various areas in the central nervous system using neurophysiological, neuropharmacological and molecular genetics assessments in various mammalian animal models. Our findings suggest that cortico-reticular and cortico-cerebellar systems are involved in the "predictive postural control", and a loop with cerebral cortex cerebellum and spinal cord including muscle tone control system may play major role in the "real-time postural control".

要启动运动，基于认知信息的预测姿势控制至关重要。在持续的运动过程中，还需要根据机械感受器的感觉信号进行实时姿势控制。在本研究中，已尝试使用神经生理学，神经药物和分子遗传学评估在各种哺乳动物动物模型中使用神经生理学，神经药物和分子遗传学评估进行研究，以检查中枢神经系统中各个区域的姿势和运动的整合机制。我们的发现表明，皮质 - 视网膜和皮质核心系统参与“预测性姿势控制”，并且具有大脑皮层小脑和脊髓（包括肌肉张力控制系统）的环可能在“实时姿势控制”中起主要作用。

项目成果

Effects of injecting GABAergic agents into the medullary reticular formation upon swallowing induced by the superior laryngeal nerve stimulation in decerebrate cats

• DOI: 10.1016/j.neures.2004.12.007
• 发表时间: 2005-04-01
• 期刊: NEUROSCIENCE RESEARCH
• 影响因子: 2.9
• 作者: Harada, H;Takakusaki, K;Sakamoto, T
• 通讯作者: Sakamoto, T

Shortening of subjective tone intervals followed by repetitive tone stimuli

• DOI: 10.3758/app.72.2.492
• 发表时间: 2010-02-01
• 期刊: ATTENTION PERCEPTION & PSYCHOPHYSICS
• 影响因子: 1.7
• 作者: Ono, Fuminori;Kitazawa, Shigeru
• 通讯作者: Kitazawa, Shigeru

Referral of tactile sensation to the tips of L-shaped sticks.

• DOI: 10.1152/jn.01015.2004
• 发表时间: 2005-05
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Shinya Yamamoto;S. Moizumi;S. Kitazawa

Extraction of Behavior Primitives in Human Standing-Up Motion for Development of Power Assisting Machine

人体站立运动行为原语的提取用于助力机的开发

• 发表时间: 2009
• 作者: Q.An;Y.Ikemoto;H.Asama;H.Matsuoka;D.Chugo;K.Takakusaki
• 通讯作者: K.Takakusaki

視空間性ワーキングメモリ課題に伴う脳活動部位の変化:脳磁場計測による検討

与视觉空间工作记忆任务相关的大脑活动区域的变化：使用大脑磁场测量的研究

• 发表时间: 2009
• 作者: 竹田里江;矢澤省吾;村原貴史;豊島貴信;石黒雅敬;白石秀明;松山清治;長峯隆
• 通讯作者: 長峯隆