Neuronal mechanisms of initiation and selection of adaptive locomotor behaviors

为了启动运动，基于认知信息的预测性姿势控制是必不可少的。在正在进行的运动中，依赖于机械感受器的感觉信号的实时姿势控制也是必需的。在本研究中，我们利用神经生理学、神经药理学和分子遗传学的方法，在不同的哺乳动物模型中研究了中枢神经系统中不同区域的姿势和运动的综合机制。我们的研究结果表明，皮质-网状系统和皮质-小脑系统参与了“预测姿势控制”，而大脑皮质-小脑和脊髓包括肌张力控制系统的回路可能在“实时姿势控制”中起主要作用。

To initiate locomotion, predictive postural control based on cognitive information is essential. During ongoing locomotion, real-time postural control depending on sensory signals from mechanoreceptors is also required. In the present study, attempts have been made to examine integrate mechanisms of posture and locomotion in the various areas in the central nervous system using neurophysiological, neuropharmacological and molecular genetics assessments in various mammalian animal models. Our findings suggest that cortico-reticular and cortico-cerebellar systems are involved in the "predictive postural control", and a loop with cerebral cortex cerebellum and spinal cord including muscle tone control system may play major role in the "real-time postural control".