Development of Molecular Transformation by the Catalyst Usable under Protic Conditions

通常，带有质子部分的底物难以用作催化反应的起始材料，因为质子条件导致催化剂分解。在本研究中，铟或镓被发现在该条件下被用作催化反应。它们具有中等的刘易斯酸性，并且有效地活化醇而不分解催化剂。催化反应完成了醇的烷基化或氯化。

In general, substrates bearing protic moiety are difficult to use as starting materials for catalytic reactions because the protic conditions cause decompositon of the catalyst. In this research, indium or gallium were found to be used as the catalytic reactions under the conditions. They have moderate Lewis acidity and effectively activates the alcohol without decomposition of the catalyst. The catalytic reactions accomplished the alkylation or chlorination of alcohols.