Controlling cell polarity and asymmetric cell division in space and time

控制细胞极性和空间和时间上的不对称细胞分裂

• 批准号: DP160104892
• 负责人: Prof John Carroll
• 金额: $ 23.51万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104892
• 关键词: Controlling; cell; polarity; asymmetric; division

This project seeks to increase our understanding of how cells divide. Asymmetric cell division is a specialised form of cell division essential for the development of all organisms. The two meiotic divisions of the oocyte are extreme examples of asymmetric cell division that allow a reduction in chromosome content while retaining cytoplasmic vestments necessary for development. Successful asymmetric cell division requires the integration of cell cycle events with cell polarity. Understanding how this is achieved would improve our understanding of how to generate a healthy embryo in women, endangered species and in animals of commercial importance.

这个项目试图增加我们对细胞如何分裂的理解。不对称细胞分裂是一种特殊的细胞分裂形式，对所有生物体的发育都是必不可少的。卵母细胞的两次减数分裂是不对称细胞分裂的极端例子，它允许减少染色体内容，同时保留发育所需的细胞质外衣。成功的不对称细胞分裂需要细胞周期事件与细胞极性的整合。了解这一点是如何实现的，将提高我们对如何在女性、濒危物种和具有商业价值的动物身上产生健康胚胎的理解。