Identification of T cells that exhibit cytotoxic activity against tumor based on the single-cell gene expression profiles and control their function

基于单细胞基因表达谱鉴定具有抗肿瘤细胞毒活性的 T 细胞并控制其功能

• 批准号: 15K18446
• 负责人: Morimoto Soyoko
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K18446/
• 关键词: single cell RT-PCR; WT1 specific CTLs; memory; WT1特異的CTL; single cell; TCR; single cell定量PCR

项目成果

Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis.

• DOI: 10.1371/journal.pone.0152326
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Hasegawa K;Tanaka S;Fujiki F;Morimoto S;Nakano K;Kinoshita H;Okumura A;Fujioka Y;Urakawa R;Nakajima H;Tatsumi N;Nakata J;Takashima S;Nishida S;Tsuboi A;Oka Y;Oji Y;Miyoshi E;Hirata T;Kumanogoh A;Sugiyama H;Hosen N
• 通讯作者: Hosen N

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide.

• DOI: 10.1002/ijc.30182
• 发表时间: 2016-09-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Oji, Yusuke;Hashimoto, Naoya;Tsuboi, Akihiro;Murakami, Yui;Iwai, Miki;Kagawa, Naoki;Chiba, Yasuyoshi;Izumoto, Shuichi;Elisseeva, Olga;Ichinohasama, Ryo;Sakamoto, Junichi;Morita, Satoshi;Nakajima, Hiroko;Takashima, Satoshi;Nakae, Yoshiki;Nakata, Jun;Kawakami, Manabu;Nishida, Sumiyuki;Hosen, Naoki;Fujiki, Fumihiro;Morimoto, Soyoko;Adachi, Mayuko;Iwamoto, Masahiro;Oka, Yoshihiro;Yoshimine, Toshiki;Sugiyama, Haruo
• 通讯作者: Sugiyama, Haruo

Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms.

• DOI: 10.1371/journal.pone.0130578
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Tatsumi N;Hojo N;Sakamoto H;Inaba R;Moriguchi N;Matsuno K;Fukuda M;Matsumura A;Hayashi S;Morimoto S;Nakata J;Fujiki F;Nishida S;Nakajima H;Tsuboi A;Oka Y;Hosen N;Sugiyama H;Oji Y
• 通讯作者: Oji Y

進行膵癌に対するゲムシタビン併用WT1ワクチン療法ランダム化第II創臨床試験：臨床効果と抗原特異的免疫反応の評価

WT1疫苗联合吉西他滨治疗晚期胰腺癌的随机II期临床试验：临床疗效和抗原特异性免疫反应评价

• 发表时间: 2016
• 作者: 西田 純幸;石川 剛;江川 新一;小井戸 薫雄;森本 創世子;石井 淳;菅野 良秀;柳本 泰明;大庭 真梨;古倉 聡;本間 定;島田 英昭;森田 智視;岡 芳弘;杉山 治夫
• 通讯作者: 杉山 治夫

Randamized phase II stuy of WT1 peptide vaccine plus gemcitabine for advanced pancreatic ductal adenocarcinoma (PDAC): Clinical efficacy and immune response

WT1 肽疫苗联合吉西他滨治疗晚期胰腺导管腺癌 (PDAC) 的随机 II 期研究：临床疗效和免疫反应

• 发表时间: 2016
• 作者: Sumiyuki Nishida;Takeshi Ishikawa;Satoshi Kokura;Shinichi Egawa;Shigeo Koido;Hiroaki Yasuda;Hiroaki Yanagimoto;Jun Ishii;Yoshihide Kanno;Mari Saito Oba;Maho Sato;Soyoko Morimoto;Hidetoshi Eguchi;Hiroaki Nagano;Sadamu Homma;Yoshihiro Oka;Sa
• 通讯作者: Sa