Study on the drug exercise therapy that is effective for cardiac hypertrophy heart failure that develops in Ca2 + load model mouse

药物运动疗法对钙负荷模型小鼠心肌肥厚性心力衰竭有效的研究

• 批准号: 15K18975
• 负责人: JIN MEIHUA
• 金额: $ 2.66万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K18975/
• 关键词: heart failure; hypertrophy; hypoxia; Ca2+-binding protein; 肺高血圧; 心肥大; Ca2+結合蛋白質; 低酸素負荷; CHP3欠損マウス; 心不全; ＮＨＥ１; Ca2+シグナル; ベータ遮断薬; CHP3

项目成果

Production of calcineurin B homologous protein 3 knockout mice and analysis of cardiac function

钙调神经磷酸酶B同源蛋白3敲除小鼠的制作及心功能分析

• 发表时间: 2016
• 作者: Shigeo Wakabayashi,MeiHua Jin;Soushi Kobayashi;Hirotsugu Tsuchimochi;Mikiyasu Shirai
• 通讯作者: Mikiyasu Shirai

Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.

• DOI: 10.1007/s12576-016-0509-5
• 发表时间: 2018-01
• 期刊: The journal of physiological sciences : JPS
• 作者: Jin H;Fujita T;Jin M;Kurotani R;Hidaka Y;Cai W;Suita K;Prajapati R;Liang C;Ohnuki Y;Mototani Y;Umemura M;Yokoyama U;Sato M;Okumura S;Ishikawa Y
• 通讯作者: Ishikawa Y

A Novel Role of Calcineurin B Homologous Protein 3 in Hypoxia-induced Cardiac Hypertrophy and Heart Failure

钙调神经磷酸酶 B 同源蛋白 3 在缺氧诱导的心脏肥大和心力衰竭中的新作用

• 发表时间: 2017
• 作者: MeiHua Jin;Shigeo Wakabayashi;Soushi Kobayashi;Hirotsugu Tsuchimochi;Mikiyasu Shirai;James T. Pearson;Takeshi Ogo.
• 通讯作者: Takeshi Ogo.

Effect of inflammatory factor-induced cyclo-oxygenase expression on the development of reperfusion-related no-reflow phenomenon in acute myocardial infarction

• DOI: 10.1111/1440-1681.12339
• 发表时间: 2015-02-01
• 期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
• 影响因子: 2.9
• 作者: Jiao, Qibin;Ke, Qiang;Zhang, Xingwei
• 通讯作者: Zhang, Xingwei

Heterozygous deletion of sarcolipin maintains normal cardiac function.

肌磷脂的杂合缺失维持正常的心脏功能。

• DOI: 10.1152/ajpheart.00411.2015
• 发表时间: 2015
• 期刊: Am J Physiol Heart Circ Physiol.
• 作者: Shimura D;Kusakari Y;Sasano T;Nakashima Y;Nakai G;Jiao Q;Jin M;Yokota T;Ishikawa Y;Nakano A;Goda N;Minamisawa S.
• 通讯作者: Minamisawa S.