Improvement of peripheral neuropathy by Adeno-associated virus vector expressing a-galactosidase A in murine Fabry model

表达α-半乳糖苷酶A的腺相关病毒载体在小鼠法布里模型中改善周围神经病变

• 批准号: 15K19637
• 负责人: HIGUCHI TAKASHI
• 金额: $ 2.5万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K19637/
• 关键词: アンダーソン・ファブリー病; 末梢神経症状; 痛み; ファブリ病; 疼痛; Gb3; Anderson-Fabry Disease; α-galactosidase A; globotriaosylceramide; TRP channel; dorsal root ganglion; ファブリー病; 末梢神経障害

项目成果

Therapeutic strategy for Fabry disease peripheral neuropathy with rAAV vector

rAAV载体治疗法布里病周围神经病的策略

• 发表时间: 2017
• 作者: TAKASHI HIGUCHI;YOHTA SHIMADA;HIROMI HIRAKI;HIROSHI KOBAYASHI;TAKAHIRO FUKUDA;FUSAO KATO;TOYA OHASHI
• 通讯作者: TOYA OHASHI

Improvement of peripheral neuropathy in murine Fabry model by intrathecal administration of serotype 9 Adeno-associated virus vector expressing α-galactosidase A

鞘内注射表达α-半乳糖苷酶A的血清型9腺相关病毒载体改善小鼠法布里模型周围神经病变

• 发表时间: 2017
• 作者: TAKASHI HIGUCHI;YOHTA SHIMADA;HIROSHI KOBAYASHI;TAKAHIRO FUKUDA;HIDETOSHI KABURAGI;MITSUHIRO ENOMOTO;FUSAO KATO;HIROYUKI IDA;TOYA OHASHI
• 通讯作者: TOYA OHASHI

Treatment for Anderson-Fabry disease peripheral neuropathy with adeno-associated virus vector encoded human α- galactosidase A gene in a murine model of Fabry disease

在法布里病小鼠模型中用腺相关病毒载体编码的人 α-半乳糖苷酶 A 基因治疗安德森-法布里病周围神经病变

• 发表时间: 2016
• 作者: T Higuchi;Y Shimada;H Kobayashi;H Ida;T Ohashi
• 通讯作者: T Ohashi

Treatment for Fabry peripheral neuropathy with Adeno-Associated Virus Vector in Murine Fabry Disease Model

腺相关病毒载体在小鼠法布里病模型中治疗法布里周围神经病

• 发表时间: 2016
• 作者: T HIGUCHI;Y SHIMADA;H KOBAYASHI;T OHASHI
• 通讯作者: T OHASHI