Novel therapeutic strategy targeting EpCAM-positive ovarian cancer stem cells

针对 EpCAM 阳性卵巢癌干细胞的新治疗策略

• 批准号: 15K20151
• 负责人: Motohara Takeshi
• 金额: $ 2.5万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K20151/
• 关键词: 卵巣癌; 癌幹細胞; 抗癌剤治療抵抗性; EpCAM; EpCAM陽性細胞

项目成果

CD44 variant 6 is correlated with peritoneal dissemination and poor prognosis in patients with advanced epithelial ovarian cancer.

• DOI: 10.1111/cas.12765
• 发表时间: 2015-10
• 期刊: Cancer science
• 影响因子: 5.7
• 作者: Tjhay F;Motohara T;Tayama S;Narantuya D;Fujimoto K;Guo J;Sakaguchi I;Honda R;Tashiro H;Katabuchi H
• 通讯作者: Katabuchi H

Emerging role of CD44 variant 6 in driving the metastatic journey of ovarian cancer stem cells. Cell Biology of the Ovary.

CD44 变体 6 在驱动卵巢癌干细胞转移过程中的新作用。

• 发表时间: 2018
• 作者: Motohara T;Katabuchi H
• 通讯作者: Katabuchi H

Radical resection of an endometrioid carcinoma arising from endometriosis in the round ligament within the right canal of Nuck: a case report and literature review.

• DOI: 10.1016/j.gore.2018.01.010
• 发表时间: 2018-05
• 期刊: Gynecologic oncology reports
• 影响因子: 1.2
• 作者: Motooka Y;Motohara T;Honda R;Tashiro H;Mikami Y;Katabuchi H
• 通讯作者: Katabuchi H

Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche

• DOI: 10.1016/j.ccell.2016.06.020
• 发表时间: 2016-08-08
• 期刊: CANCER CELL
• 影响因子: 50.3
• 作者: Miranda, Fabrizio;Mannion, David;Ahmed, Ahmed Ashour
• 通讯作者: Ahmed, Ahmed Ashour

Cancer stem cell marker EpCAM is involved in resistance to chemotherapy and poor prognosis in ovarian cancer patients

癌症干细胞标志物EpCAM与卵巢癌患者化疗耐药和不良预后有关

• 发表时间: 2018
• 作者: Tjhay F;Motohara T;Tayama S;Narantuya D;Fujimoto K;Guo J;Sakaguchi I;Honda R;Tashiro H;Katabuchi H.;Takeshi Motohara
• 通讯作者: Takeshi Motohara