Determination of the mechanisms of immune system regulation of inflammation by the human protein, chaperonin 10

确定人类蛋白伴侣蛋白 10 免疫系统调节炎症的机制

• 批准号: LP0560289
• 负责人: Em/Prof Stephen Mahler
• 金额: $ 24.93万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0560289
• 关键词: Determination; mechanisms; immune; system; regulation

The aim of this project is to determine the mechanisms by which a human protein, chaperonin 10 (Cpn10), regulates the immune system and suppresses inflammation. When cells of the human immune system are challenged with lipopolysaccharide (LPS) (a product of bacterial infection), the pro-inflammatory cytokine TNF is released. Cpn10 has been shown to suppress production of TNF on challenge of cells with LPS, while increasing the levels of the anti-inflammatory cytokine IL-10. Investigating the role of Cpn10 in modulating inflammation will contribute to the understanding and treatment of diseases associated with inflammation, including multiple sclerosis and rheumatoid arthritis.

该项目的目的是确定人类蛋白质伴侣蛋白10（Cpn 10）调节免疫系统和抑制炎症的机制。当人类免疫系统的细胞受到脂多糖（LPS）（细菌感染的产物）的攻击时，释放促炎细胞因子TNF。 Cpn 10已显示在用LPS攻击细胞时抑制TNF的产生，同时增加抗炎细胞因子IL-10的水平。 研究Cpn 10在调节炎症中的作用将有助于理解和治疗与炎症相关的疾病，包括多发性硬化症和类风湿性关节炎。