In Vivo Imaging System for small animals

小动物体内成像系统

• 批准号: 507819541
• 金额: --
• 依托单位: Charité - Universitätsmedizin Berlin
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2022
• 资助国家: 德国
• 起止时间: 2021-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/507819541?language=en
• 关键词: Vivo; Imaging; System; small; animals

Animal studies are essential for investigating complex biological processes and diseases. The research projects of the applicants apply “in vivo live imaging” studies in tumor biology and therapy, inflammation and immunology, cardiovascular and neurological diseases. The instrument should enable multiparametric, high-resolution luminescence and fluorescence analyses in small animals in order to obtain insight into the development of diseases and test novel therapeutic approaches. The following specifications are required: 1) non-invasive 2D Fluorescence- and Bioluminescence imaging of several mice in parallel; 2) fast 2D Trans-Illumination for high sensitivity of fluorescence-tomography in deep-set tissues; 3) 3D imaging to exactly assess the spatial distribution of diseases such as tumors or inflammation; 4) multiparametric studies of several fluorescence markers together with luminescence to enable analyses of complex interactions of different cell types; 6) analyses tools according to international standard for a better comparison to published studies; 7) an integrated anesthesiology device for efficient conduction of the experiments

动物研究对于研究复杂的生物过程和疾病至关重要。申请人的研究项目应用于肿瘤生物学和治疗、炎症和免疫学、心血管和神经系统疾病的“体内活体成像”研究。该仪器应能够在小动物中进行多参数，高分辨率的发光和荧光分析，以深入了解疾病的发展并测试新的治疗方法。需要以下规格：1）并行对多只小鼠进行非侵入性2D荧光和生物发光成像; 2）快速2D Trans-Illumination，实现深层组织荧光断层扫描的高灵敏度; 3）3D成像，准确评估肿瘤或炎症等疾病的空间分布; 4）几种荧光标记物与发光的多参数研究，使得能够分析不同细胞类型的复杂相互作用; 6）根据国际标准分析工具，以便与已发表的研究进行更好的比较; 7）用于有效进行实验的集成麻醉设备