The Role of Dendritic Cells on the Intestinal Stem Cell Niche

树突状细胞对肠干细胞生态位的作用

• 批准号: 17K15717
• 负责人: IHARA SOZABURO
• 金额: $ 2.66万
• 依托单位: The Institute for Adult Diseases Asahi Life Foundation
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17K15717/
• 关键词: 炎症性腸疾患; 樹状細胞; 腸オルガノイド; 幹細胞; 腸上皮分化異常; Notchシグナル; 腸管免疫; 腸管上皮幹細胞; オルガノイド培養

项目成果

Abrogation of TGF-beta Signaling in Dendritic Cells Leads to E-cadherin-mediated Adhesion between Dendritic Cells and Epithelium which Contribute to the Pathogenesis of Inflammatory Bowel Disease

树突状细胞中 TGF-β 信号传导的消除会导致树突状细胞和上皮细胞之间 E-钙粘蛋白介导的粘附，从而导致炎症性肠病的发病机制

• 发表时间: 2018
• 作者: Ihara Sozaburo;Hirata Yoshihiro;Hikiba Yohko;Yamashita Aya;Tsuboi Mayo;Hata Masahiro;Konishi Mitsuru;Suzuki Nobumi;Sakitani Kosuke;Kinoshita Hiroto;Hayakawa Yoku;Nakagawa Hayato;Ijichi Hideaki;Tateishi Keisuke;Koike Kazuhiko;Sozaburo Ihara
• 通讯作者: Sozaburo Ihara

3D Co-culture System of Intestinal Organoids and Dendritic Cells to Study Epithelial Differentiation

用于研究上皮分化的肠类器官和树突状细胞 3D 共培养系统

• 发表时间: 2017
• 作者: Ihara Sozaburo;Hirata Yoshihiro;Hikiba Yohko;Yamashita Aya;Tsuboi Mayo;Hata Masahiro;Konishi Mitsuru;Suzuki Nobumi;Sakitani Kosuke;Kinoshita Hiroto;Hayakawa Yoku;Nakagawa Hayato;Ijichi Hideaki;Tateishi Keisuke;Koike Kazuhiko;Sozaburo Ihara;井原聡三郎;井原聡三郎
• 通讯作者: 井原聡三郎

Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease

• DOI: 10.1093/ecco-jcc/jjy088
• 发表时间: 2018-10-01
• 期刊: JOURNAL OF CROHNS & COLITIS
• 影响因子: 8
• 作者: Ihara, Sozaburo;Hirata, Yoshihiro;Koike, Kazuhiko
• 通讯作者: Koike, Kazuhiko

炎症性腸疾患における樹状細胞・腸上皮間のNotchシグナルを介した相互作用

Notch信号介导的炎症性肠病中树突状细胞和肠上皮之间的相互作用

• 发表时间: 2018
• 作者: Ihara Sozaburo;Hirata Yoshihiro;Hikiba Yohko;Yamashita Aya;Tsuboi Mayo;Hata Masahiro;Konishi Mitsuru;Suzuki Nobumi;Sakitani Kosuke;Kinoshita Hiroto;Hayakawa Yoku;Nakagawa Hayato;Ijichi Hideaki;Tateishi Keisuke;Koike Kazuhiko;Sozaburo Ihara;井原聡三郎
• 通讯作者: 井原聡三郎

Adhesive interactions between dendritic cells and epithelium contribute to IBD pathogenesis

树突状细胞和上皮之间的粘附相互作用促进 IBD 发病机制

• 发表时间: 2017
• 作者: Ihara Sozaburo;Hirata Yoshihiro;Hikiba Yohko;Yamashita Aya;Tsuboi Mayo;Hata Masahiro;Konishi Mitsuru;Suzuki Nobumi;Sakitani Kosuke;Kinoshita Hiroto;Hayakawa Yoku;Nakagawa Hayato;Ijichi Hideaki;Tateishi Keisuke;Koike Kazuhiko;Sozaburo Ihara;井原聡三郎;井原聡三郎;井原聡三郎
• 通讯作者: 井原聡三郎