Elucidation of the switching mechanism for induction of cell death of FGF signal by IL1b in articular cartilage

阐明关节软骨中 IL1b 诱导 FGF 信号细胞死亡的转换机制

• 批准号: 17K16678
• 负责人: KATAGIRI HIROKI
• 金额: $ 2.58万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17K16678/
• 关键词: 変形性膝関節症; IL1b; FGFレセプター; 疾患修飾型治療薬; 軟骨細胞; 軟骨変性機序; 膝軟骨損傷; FGF2; FGFR3; FGFR１; IL１; 炎症; シグナル伝達

项目成果

Underlying mechanisms in the reduction of BMP-induced bone formation in immunocompetent compared to nude mice

与裸鼠相比，免疫功能正常的小鼠中 BMP 诱导的骨形成减少的潜在机制

• 发表时间: 2018
• 作者: H Katagiri;Mendes LF;Luyten FP.
• 通讯作者: Luyten FP.

Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone.

• DOI: 10.1186/s12891-018-2221-5
• 发表时间: 2018-08-16
• 期刊: BMC musculoskeletal disorders
• 影响因子: 2.3
• 作者: Hoshino T;Tsuji K;Onuma H;Udo M;Ueki H;Akiyama M;Abula K;Katagiri H;Miyatake K;Watanabe T;Sekiya I;Koga H;Muneta T
• 通讯作者: Muneta T