Elucidation of a new mechanism by which pregnancy suppresses neuropathic pain: Focusing on reactive oxygen species

阐明妊娠抑制神经性疼痛的新机制：关注活性氧

• 批准号: 17K16716
• 负责人: Onodera Yoshiko
• 金额: $ 2.5万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17K16716/
• 关键词: 神経障害性疼痛; 妊娠; 活性酸素

项目成果

Pregnancy Attenuates the Expression of TLR4 and Drp1 in the Spinal Cord of Rats With Neuropathic Pain

怀孕会减弱神经性疼痛大鼠脊髓中 TLR4 和 Drp1 的表达

• 发表时间: 2017
• 作者: Chinami Takahashi;Megumi Kanao-Kanda;Hirotsugu Kanda;Yoshiko Onodera;Izumi Sato;Takafumi Iida;Hiroshi Iwasaki;Takayuki Kunisawa.
• 通讯作者: Takayuki Kunisawa.

Pregnancy Suppresses Mechanical Allodynia by Reversing the Downregulation of GAD67 in the Spinal Dorsal Horn in the Chronic Constriction Injury Rat Model

妊娠通过逆转慢性缩窄性损伤大鼠模型脊髓背角 GAD67 的下调来抑制机械性异常性疼痛

• 发表时间: 2017
• 作者: Izumi Sato;M.D.;Megumi Kanda-Kanao;M.D.,Ph.D.;Yoshiko Onodera;M.D.;Chie Mori;M.D.;Takafumi Iida;M.D.,Ph.D.;Hirotsugu Kanda;M.D.,Ph.D.;Hiroshi Iwasaki;M.D.,Ph.D.;Takayuki Kunisawa;M.D.,Ph.D.
• 通讯作者: M.D.,Ph.D.

Pregnancy suppresses mechanical allodynia by reversing decreased mitochondrial SIRT3 in the spinal dorsal horn in the chronic constriction injury rat model

妊娠通过逆转慢性缩窄性损伤大鼠模型中脊髓背角线粒体 SIRT3 的减少来抑制机械性异常性疼痛

• 发表时间: 2018
• 作者: Eri Anno;Megumi Kanao-Kanda;Izumi Sato;Yoshiko Onodera;Hirotsugu Kanda;Chie Mori;Hiroshi Iwasaki;Takayuki Kunisawa
• 通讯作者: Takayuki Kunisawa