Role of ETV transcription factors in atrial cardiomyopathy (B08)

ETV转录因子在心房性心肌病中的作用（B08）

• 批准号: 508144737
• 金额: --
• 依托单位: Klinik für Kardiologie, Angiologie und Pulmologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/508144737?language=en
• 关键词: Role; ETV; transcription; factors; atrial

Atrial cardiomyopathy is a complex and heterogenous disease that occurs in context of various clinical backgrounds. The molecular circuits of atrial cardiomyopathy have not been well characterized, which also explains the lack of efficient therapies. ETV transcription factors driven gene regulation was shown for various genes as KCNK3 that are involved in atrial remodelling processes. We will dissect how ETV1-7 transcription factors are involved in the regulation of the atrial KCNK3 potassium ion channel as well as the development of atrial cardiomyopathy subtypes and how they control chamber-specific transcriptional responses. Understanding the underlying mechanisms will be important for identifying new therapeutic targets.

心房心肌病是一种复杂的异质性疾病，发生在不同的临床背景。心房心肌病的分子回路尚未得到很好的表征，这也解释了缺乏有效的治疗方法。ETV转录因子驱动的基因调控显示了参与心房重构过程的各种基因，如KCNK 3。我们将剖析ETV 1 -7转录因子如何参与心房KCNK 3钾离子通道的调节以及心房心肌病亚型的发展，以及它们如何控制室特异性转录反应。了解潜在的机制将是重要的，以确定新的治疗目标。