Molecular mechanism of bacterial signal transduction

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Bacteria have evolved two-component signal transduction systems (TCS), which are comprisedof sensor histidine kinases(HK) and theircognate response regulators(RR, transcriptional factor). Bacterial cells have a number of TCSs to respond to various environmental stresses. Comprehensive transcriptome studies of these TCSs suggest that they interact with each other by means of a signal transduction network. In Escherichia colicells, we haveclarified the molecular mechanism of how EvgS/EvgA TCS connects to PhoQ/PhoP TCS via a connector SafA.