Total Control of Psycho-immune-endocrine system ; revealing stress specific cytokine cascade

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In this study, we have revealed (1) human serological marker to objectify what and how much stress is loaded, (2) a pathway for cytokine induction via interleukin(IL) 18, superoxide, and tumor-necrotizing-factor, (3) a pathway for cytokine induction involving mitochondria, (4) a human serological marker that associates with severity of major depressive disease, and (5) a human serological marker that predicts psycho-behavioral disorders after stress. We have reported these results in several academic meeting including plenary lectures. At the same time, our developed technique to objectify post-stress depression have been practically utilized for people participated to rescue operation of the Tohoku Earthquake.