Establishment of magnetic hyperthermic prostate cancer therapy using brachytherapy systems

为实现局部放疗和局部热疗的联合治疗，利用前列腺癌治疗用小粒子同时作为磁热治疗的加热介质，实现了副作用小、疗效高的联合治疗。体内实验表明，在1 MHz、50Oe-rms的交换磁场作用下，钛针作为小粒种子的冷假人，具有足够的磁热介质作用。此外，还发现血液中的热休克蛋白(据说是为了提高免疫效果)浓度故意变高。这意味着，当小种子被用作加热媒介时，不仅需要放射和热疗，还需要免疫疗法。

Basic studies were performed to realize the combined therapy of the local radiation and the local hyperthermic treatments with less side-effects and high curative effect utilizing small seeds used for prostate cancer treatment also as heating mediators in magnetic hyperthermia. When applying the exchange magnetic field of 1 MHz and 50 Oe-rms, Ti needles, used as cold dummy of small seeds, functioned enough as heating mediators of magnetic hyperthermia through in-vivo tests. Moreover, it was found that the heat-shock protein(said to heighten the immunity effect) concentration in blood became high intentionally. This means that not only radiation and hyperthermia but also immune-therapies were expected when small seeds were used as heating mediators.