Analysis of dynamic structure-function network of heterochromatin

异染色质是表观遗传基因调控和维持遗传信息的重要物质。我们以裂变酵母为模式生物，重点研究rnai介导的异染色质形成，并试图了解其形成和功能的分子机制。我们揭示了调控异染色质形成和功能的一部分转录因子网络。此外，我们还提出了一个新的概念：rnai导向的异染色质形成工厂在核周围形成。

Heterochromatin is an important for epigenetic gene regulation and maintenance of genetic information. Using fission yeast as a model organism, we focused on RNAi-directed heterochromatin formation and tried to understand the molecular mechanism of its formation and function. We revealed a part of network of transcription factors that regulate the formation and function of heterochromatin. In addition, we also presented a novel concept : factory for RNAi-directed heterochromatin formation is formed at nuclear periphery.